Front Matter
Rang and Dale’s Pharmacology
H P Rang MB BS MA DPhil Hon FBPharmacolS FMedSci FRS
Emeritus Professor of Pharmacology, University College London, London, UK
Senior Teaching Fellow, Department of Pharmacology, University of Oxford, Oxford, UK
J M Ritter DPhil FRCP FBPharmacolS FMedSci
Emeritus Professor of Clinical Pharmacology, King’s College London, London, UK
R J Flower PhD DSc FBPharmacolS FMedSci FRS
Professor, Biochemical Pharmacology, The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
G Henderson BSc PhD FBPharmacolS
Professor of Pharmacology, University of Bristol, Bristol, UK
Edinburgh, London, New York, Oxford, Philadelphia, St Louis, Sydney, Toronto 2012
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Cover image shows white blood cells emigrating from blood vessels.
The inner surface of blood vessels are lined with endothelial cells which express a protein called PECAM-1 at the junction between cells, and less strongly on the cell body. This protein was labelled red with a fluorescently tagged antibody, and genetic modification was used to make the white blood cells (leukocytes) express green fluorescent protein. These can be seen sticking to the endothelial cells, and beginning to transmigrate through the blood vessel wall in response to an inflammatory stimulus.
The image was captured by confocal microscopy with laser excitation of the green and red fluorescent labels. A series of flat images through the vessel were taken, and these slices were reconstructed to make a 3D object.
Image generated by S. Nourshagh, A. Woodfin and M. Benoit-Voisin (William Harvey Research Institute, London).
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