3

Pharmacological behaviour management

Eduardo A Alcaino, Jane McDonald, Michael G Cooper and Simrit Malhi

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Pain management for children

The proper treatment of pain in children is often inadequate and involves misconceptions that:

• Children experience less pain than adults.

• Neonates do not feel or remember pain.

• Pain is character-building for children.

• Opioids are addictive and too dangerous in terms of respiratory distress.

• Children cannot localize or describe their pain.

Analgesia prior to procedures (pre-emptive analgesia)

• Poor analgesia for an initial procedure in children can diminish the efficacy of analgesia for subsequent similar procedures.

• Consideration should be given to ensure adequate systemic and/or local analgesia prior to the commencement of a procedure. Appropriate time for absorption and effect should be allowed.

• A stronger analgesic may be required for the procedure with regular simple analgesics for the postoperative period.

Analgesics

See Table 3.1.

Local anaesthesia

The use of local anaesthesia in paediatric dentistry varies significantly between countries and there are also individual preferences. Every clinician must be proficient at administering painless local anaesthesia. While it is the mainstay of our pain control for operative treatment, it also represents one of the greatest fears in our patients. Use of many of the non-pharmacological techniques described in the previous chapter may enable the dentist to deliver an injection without the child being aware. There are few patients, old or young, who are not genuinely afraid of injections, and there are obvious disadvantages in the physical size of the dental cartridge syringe.

Techniques and tips

• It makes sense NOT to hold the syringe in front of a young child to see. While it is essential not to lie to the child, distractions such as having the dental assistant talk, or use of the low velocity suction are useful.

• The use of topical anaesthetics is essential to create the optimal experience for the child. While a multitude of agents are available with different flavours and properties, newer anaesthetics such as EMLA® (Eutectic Mixture of Local Anaesthetic) penetrate deeper through the mucosa.

• Newer products such as electronic devices for slow injection techniques may replace more conventional techniques (The Wand®).

• The use of infiltration versus block injections in the mandible is also the subject of debate, and clinicians differ in their choice of technique. The approach of the needle to the mandibular foramen differs in younger children, as the angle of the mandible is more obtuse and a shorter needle (25 mm) may be sufficient. However, even with the best technique, a mandibular block injection may still be uncomfortable.

• Infiltration injections supplemented with intra-periodontal injection may be useful.

• Palatal anaesthesia is best achieved by slowly infiltrating through the inter-dental papilla after adequate labial or buccal anaesthesia to minimize discomfort to the child (Figure 3.1).

Complications with local anaesthesia

The most significant complication encountered is overdosage. Consequently, maximum doses (Table 3.2) need to be calculated according to weight and preferably written in the notes if more than just a short procedure is being performed. This clinical complication is highlighted in a paper that reviewed significant negative outcomes (death or neurological damage) in children due to local anaesthetic overdose (Goodson & Moore 1983).

Other complications include:

• Failure to adequately anaesthetize the area.

• Intravascular injection (inferior alveolar nerve blocks or, infiltration in the posterior maxillae, directly into the pterygoid venous plexus).

• Biting of the lower lip or tongue postoperatively.

• Facial nerve paralysis by injecting too far posteriorly into the parotid gland.

Consequently, adequate postoperative instructions to both children and parents are necessary to minimize these complications. In addition, inadequate local anaesthetic technique (inexperienced operator, fast delivery of solution and inadequate behaviour management) may jeopardize a successful outcome in an otherwise cooperative child. Allergic reactions to local anaesthetic solutions and needle breakage are rare in children.

The use of articaine with adrenaline has gained popularity recently. However, its safety and effectiveness in children under the age of 4 years has not been established. Finally, it is worth noting that there is significant evidence that inadequate local anaesthesia for initial procedures in young children may diminish the effect of adequate analgesia in subsequent procedures (Weisman et al. 1998).

Sedation in paediatric dentistry

The decision to sedate a child requires careful consideration by an experienced team. The choice of a particular technique, sedative agent and route of delivery should be made at a prior consultation appointment to determine the suitability of the child (and their parents) to a specific technique.

The use of any form of sedation in children presents added challenges to the clinician. During sedation, a child’s responses are more unpredictable than that of adults. Their proportionally smaller bodies are less tolerant to sedative agents and they may be easily over-sedated. Anatomically differences in the paediatric airways include:

• The vocal cords positioned higher and more anterior.

• The smallest portion of paediatric airway is at the level of the subglottis (below cords) at the level of the cricoid ring.

• Children have relatively larger tongue and epiglottis.

• Possible presence of large tonsillar/adenoid mass (Figure 3.2).

• Larger head to body size ratio in children.

• The mandible is less developed and retrognathic in younger children and infants.

• Children have smaller lung capacity and higher metabolic rate resulting in a smaller oxygen reserve. Hence children desaturate more quickly than adults.

Patient assessment

The preoperative assessment is among the most important factors when choosing a particular form of sedation. This assessment must include:

• A thorough medical and dental history (including current medications, previous hospitalization and past operations).

• Patient medical status (see ASA classification, below).

• History of recent respiratory illness or current infections.

• Assessment of the airway to determine suitability for conscious sedation or general anaesthesia (GA).

• Fasting requirements and the ability of the carer to comply with instructions.

• Proposed procedures being performed.

• Patient’s weight and vital signs.

The clinician should be aware that children have resting vital signs that differ according to their age (Table 3.3).

The use of monitoring devices such as pulse oximetry is desirable for lighter sedation techniques and mandatory for moderate and deep sedation. While not currently mandated during relative analgesia, it is suggested that pulse oximetry should be used in all instances when a child is sedated. Sedation and anaesthesia is a continuum and any dentist who sedates children must be capable of resuscitating the patient from any level of sedation deeper than intended (Cote & Wilson 2006). Furthermore, regulations in each country, cultural and socioeconomic factors will determine which particular approach to sedation is chosen. Parental attitudes will also determine the appropriateness of a particular sedation technique.

Pharmacological agents may be administered in a number of ways but the more common routes of delivery include:

• Inhalational sedation.

• Enteral oral sedation or rectal sedation.

• Parenteral or intravenous sedation.

• General anaesthesia.

Inhalation sedation (relative analgesia or nitrous oxide sedation)

Nitrous oxide is a weak anaesthetic agent and is extremely useful in relieving anxiety. The use of nitrous oxide (N2O) offers the clinician a safe and relatively easy technique to use as an adjunct to clinical care. It can provide a gentle introduction to operative dentistry for the very anxious patient, or an ongoing aid for those who need assistance to accept routine operative dental care. It is effective for children who are anxious but cooperative. An uncooperative child will often not allow a mask or nasal hood to be placed over the nose. It also requires a child of sufficient maturity, age or understanding to help during the dental procedure. The acceptance of the mask is usually the biggest hurdle clinically, and often it is useful to lend the mask to the child prior to their treatment visit so they can practise and familiarize themselves with it. Alternatively, a trial appointment using inhalation sedation (IS) may be beneficial and help the clinician assess the correct concentrations to be used.

Administration of inhalation sedation

For the safe and effective use of inhalation sedation, it is necessary to have a complete understanding of the different stages of analgesia and anaesthesia with N2O, the delivery machine and circuits. This requires training in its administration and the careful monitoring of children. In particular, knowledge and training in emergency responses is also essential.

• The equipment must have the capacity to deliver 100% oxygen, and never less than 30% oxygen.

• Prior to commencing sedation with N2O, always carefully inspect the apparatus and circuit for any leaks. If the reservoir bag does not inflate, examine for a tear.

• A range of fragrant nasal masks is available and useful in making the child feel more comfortable and involves them in the process by offering some choice. Offer the child the mask to take home prior to the treatment appointment, so that he/she can gain familiarity in wearing it.

Determining levels of sedation

• Once local anaesthesia has been administered successfully, the N2O should be lowered to around 30% and maintained at this level. Repeatedly adjusting the levels can be quite disconcerting and so changes should be kept to a minimum.

• Once the procedure is complete, or near completion, the concentration of gas should be lowered, so that the child is maintained on 100% oxygen. This displaces nitrous oxide from the child’s body and lessens the risk post-procedural diffusion hypoxia.

• The level at which a patient will be comfortable under IS will be different for every child. Excessive amounts of N2O may put the child into the excitement stage of anaesthesia (Guedel Stage II) and may induce vomiting, a feeling of fear or excessive movement.

Give clear postoperative instructions to the parent. The child should rest for the remainder of the day and only engage in sedentary activities. Physical activity should be avoided and the child should remain under continuous supervision.

Conscious sedation

The term ‘conscious sedation’ has been used in the past to imply a patient who is awake, responsive and able to communicate. This verbal communication with the child is an indicator of an adequate level of consciousness and maintenance of protective reflexes. In clinical practice, however, sedation (conscious sedation, deep sedation and/or general anaesthesia) is a continuum. Any technique which depresses the CNS may result in a deeper sedation state than intended, and consequently, clinicians who sedate children require a much higher level of skill with a particular technique, the relevant training and experience and the proper qualifications with the relevant regulating authority.

Sedation of children for diagnostic and therapeutic procedures remains an area of rapid change in medicine and one of considerable controversy. Publications (Cote et al. 2000) have identified several features associated with adverse sedation-related events and poor outcomes, namely:

• Occur more frequently in a non-hospital-based facility.

• Inadequate resuscitation was more often associated with a non-hospital-based setting.

• Inadequate and inconsistent physiological monitoring.

• Often associated with drug overdoses and the use of multiple agents, especially when three or more drugs were used.

• Inadequate preoperative assessment.

• Lack of an independent observer.

• Errors in medication.

• Inadequate recovery procedures.

Oral sedation

Oral sedation is the most popular route used by paediatric dentists, due to the ease of administration for most children. There are a number of agents used for this technique including:

• Benzodiazepines (e.g. midazolam).

• Chloral hydrate.

• Hydroxyzine.

• Promethazine.

• Ketamine.

• Fentanyl.

Midazolam has increased in popularity in the last decade due to its safety and short-acting nature, allowing a quick recovery and discharge of the patient. Oral dosage varies from 0.3–0.7 mg/kg, however a maximum ceiling dose (e.g. 10 mg) is usually determined for the older age groups. There are a number of studies that report on the use of oral midazolam, as a successful technique for children with the following selection criteria:

• Children of ages 24 months to 6–8 years of age (depending on individual characteristics, e.g. body weight).

• ASA 1 or 2.

• Short or simple procedures (<30 min).

• Parents who are ‘fit’ for the technique, that is, they are able to care adequately for the child after the procedure.

Although the technique is successful in the older age groups, it may be more difficult to deal with children of larger size, once sedated. Children over 6 years may become disinhibited and there is a higher frequency of paradoxical reactions in this age group. In addition, obese children may present added airway complications and issues with pharmacokinetics of the drug. Appropriate fasting for elective procedures is preferable.

The main disadvantage of the oral route is that the drugs given cannot be titrated accurately. As most drugs undergo hepatic metabolism, only a fraction of the original dose is active. This makes titration difficult and unreliable, unlike other techniques such as IS and IV sedation. Equally, an overdose cannot be easily reversed. Oral sedation requires enough cooperation of the child to be able to take the medication orally. A child may also spit out the medication. Never re-dose, as it is impossible to accurately determine how much of the drug was ingested.

In the pre-cooperative age group, a knee-to-knee position offers good access for the delivery of oral medications. This technique is also used to treat young children as it allows good control of the patient, easy restraint by the parent/carer and good vision into the mouth by the clinician.

General anaesthesia

While it is the most expensive form of treatment, the use of general anaesthesia (GA) for dental treatment has increased globally. This is due to the increase in availability, safety, and an understanding that it is the most appropriate way in which to manage young children requiring extensive dental treatment. This is also in-line with the management of most other invasive medical procedures that are performed under anaesthesia around the world.

It is significant that mortality rates from anaesthesia have decreased around the world. In Australia, in 2005, deaths due to anaesthesia in all age groups was estimated to be 1 : 53 000. The mortality rate for children, although unable to be accurately quantified, was much lower than this, and is estimated to be 1 : 150 000. There are no available figures documenting morbidity in children arising from general anaesthesia.

Although most children will cope with dentistry in a normal setting, many may benefit from delivery of extensive dentistry in one session under GA. The decision to arrange general anaesthesia should not be taken lightly, as there are risks and although less frequent, more serious complications may arise from the anaesthetic. The clinician must make a decision balancing the need against the risk. Economic (public health access and private insurance) and cultural factors and access to anaesthetic facilities may also influence the use of GA. When deciding to place the child under general anaesthesia, the clinician must look at the whole picture.

Pre-anaesthetic assessment for general anaesthesia

A medical history and examination by the anaesthetist is required prior to the procedure. If a patient has complex medical problems, a preoperative anaesthetic assessment may be required as a separate consultation prior to the day of surgery.

The anaesthetist will particularly want to be aware of:

• Behavioural issues, e.g. autism, developmental delay, extreme anxiety and needle phobia.

• Syndromes, e.g. Down syndrome, velocardiofacial syndrome.

• Cardiac disease, heart murmurs, previous surgery for congenital defects.

• Respiratory disease, e.g. asthma.

• Airway problems, e.g. history of croup, cleft palate, micrognathia, previous tracheostomy, known history of intubation difficulties, sleep apnoea.

• Neurological disease, e.g. epilepsy, previous brain injuries, cerebral palsy.

• Endocrine and metabolic disorders, e.g. diabetes, genetic metabolic disorders.

• Gastrointestinal problems, e.g. reflux, difficulty swallowing or feeding.

• Haematological, e.g. haemophilia, thrombocytopenia, haemoglobinopathies.

• Neuromuscular disorders, e.g. muscular dystrophy.

Allergies must be noted, including latex allergy.

Medications must be documented. Most medications should be continued until the time of anaesthesia unless there is a clear reason to withhold (e.g. with anticoagulants or insulin). Consultation with the original prescriber should be made before warfarin or aspirin is ceased to make an assessment of the risk or benefit of ceasing these drugs. Management of diabetic patients will require consultation with the patient’s endocrinologist.

Upper respiratory tract infection

If a child presents with an upper respiratory tract infection on the day of surgery, it may be appropriate to delay elective anaesthesia for 2–3 weeks. This decision can be balanced against economic and social issues and patient factors such as the child’s age, urgency of treatment, severity of the infection and any other medical problems the child may have. Ultimately, the decision to cancel or proceed is up to the anaesthetist.

Operating theatre environment

There is often a misconception that everything that happens in an operating room is sterile, and unless staff are familiar with dental procedures, the experience for many children and parents can be overly bureaucratic. While clinicians must follow the protocols of the individual institution under which they operate, it is essential that auxiliary staff appreciate the anxiety that our patients feel and why they are having their treatment performed under general anaesthesia. To reduce the child’s fear and anxiety, strategies should be used to help them to cope with the operating theatre environment. For example:

• Minimizing the waiting time prior to the procedure.

• Leaving them in their own clothes. It is not necessary to change into theatre attire for routine restorative procedures.

• Allowing a parent to stay with the child during induction of anaesthesia.

• Using topical local anaesthetic cream such as EMLA® if an intravenous induction is planned.

• Allowing a parent into the recovery area to be with the child as soon as they are awake and stable.

• Reassuring parents at all stages about what to expect.

Sharing the airway (Figure 3.5)

• The anaesthetist and dentist must share the airway, so teamwork, and mutual understanding of each other’s needs, is necessary.

• Nasotracheal intubation with a nasal RAE (Ring-Adair-Elwyn) tube provides good access for the dentist and a secure airway for the anaesthetist. A throat pack is usually used and it is essential to ensure the removal of a throat pack at the end of the case.

• The throat pack should not be so bulky that the tongue is forced anteriorly limiting the access to the mouth for the dentist. In young children, reduce the size of an adult-sized pack to one-third (ribbon gauze of about 30 cm moistened with saline).

• An oral laryngeal mask airway or endotracheal tube provides a satisfactory airway for the anaesthetist, but may or may not give the dentist the access they require, as it encroaches on the work area. However, this is a useful technique for less extensive dental work, such as extractions of primary teeth after trauma or when a nasal tube is contraindicated. If a laryngeal mask airway is used, a flexible one is most appropriate, but it is a less secure airway than an endotracheal tube.

• A face-mask-only technique may be used for simple extractions. The mask is removed for a short time while the extraction is performed. However, the airway must be protected. This can be done by placing a gauze swab behind the teeth being extracted.

• During anaesthesia, it is important to protect the eyes from injury by taping them shut and possibly covering them with padding.

• Before waking the patient, all foreign material such as rolls, gauze and throat packs must be removed and accounted for.

Emergence

Ideally, parents should be able to come into the recovery area once the child is awake and in a stable condition. Distress on waking is not uncommon, and can be due to emergence delirium. The child is quite likely to be upset by the unfamiliar environment, an unpleasant taste in the mouth or because their mouth feels different because of missing teeth or new crowns.

Clinical Hints for treatment under GA

1. Pre-operative assessment, written consent and information provided to parents at the consultation visit.

2. Dental Treatment Planning. This is an important part to reduce repeat procedures under sedation.

3. Parent contacted 24 hours prior by dentist and hospital staff confirming fasting instructions and admission protocols.

4. On day of GA/surgery

a. Assessment by anaesthetist – confirms fitness of child for procedure (e.g. URTI, illnesses).

b. Assessment by dentist and treatment plan discussion with parent(s). In many cases one parent will attend the consultation and the other parent presents on the day of treatment. An important step regarding informed consent.

c. Check that all dental equipment is operational prior to commencing GA.

5. Induction. Protocol differs in each hospital but often the induction is with a parent present (current trends in paediatric GA).

6. Radiographs and Photos. In cases of dental caries and extractions, intra-oral radiographs are ‘mandatory’. The absence of X-rays during dental GA may be considered negligent in some countries. Pre-operative photos are strongly recommended to record the pre-operative status.

7. Use of Rubber Dam is strongly recommended in restorative cases. (Further protection to the airway.)

8. The use of Local Anaesthesia (LA) is not constant in all cases and highly dependent on the operator’s choice/experience. For instance LA may only be used for extractions of permanent teeth and surgical procedures.

9. Review Treatment Plan, account for all extracted teeth and disposable materials.

10. Dentist to discuss post-operative outcome with parents on the day of GA.

11. Arrange a post-GA follow up appointment.

Further reading

Pain control for children

1. Analgesic Expert Group. Therapeutic guidelines: Analgesic Version 5. Melbourne: Therapeutic Guidelines Ltd; 2007.

2. Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine. The paediatric patient In: NHMRC Acute pain management: scientific evidence. third ed Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine 2010; In: www.anzca.edu.au/publications/acutepain.htm; 2010.

3. Herschell AD, Calzada E, Eyberg SM, et al. Clinical issues with parent–child interaction therapy. Cognitive and Behavioral Practice. 2003;9:16–27.

4. Lamacraft G, Cooper MG, Cavalletto BP. Subcutaneous cannulae for morphine boluses in children: assessment of a technique. Journal of Pain Symptoms and Management. 1997;13:43–49.

5. NSW Health. Paracetamol use, 2006 PD2006_004 [policy directive]. In: www.health.nsw.gov.au/policies/pd/2006/PD2006_004.html; 2006.

6. Royal Australasian College of Physicians. Paediatrics and Child Health Division Guideline statement: Management of procedure related pain in children and adolescents. In: www.health.nsw.gov.au/policies/pd/2006/PD2006_004.html; 2005.

7. Weisman SJ, Berstein B, Schechter NL. Consequences of inadequate analgesia during painful procedures in children. Archives of Pediatrics and Adolescent Medicine. 1998;152:147–149.

8. Williams DG, Hatch DJ, Howard RF. Codeine phosphate in paediatric medicine. British Journal of Anaesthesia. 2001;86:413–421.

Sedation

1. Cote CJ, Wilson S. Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures An update. Pediatrics. 2006;118(6):2587–2602.

2. Cote CJ, Notterman DA, Karl HW, et al. Adverse sedation events in pediatrics A critical incident analysis of contributing factors. Pediatrics. 2000;105(4):805–814.

3. Cote CJ, Notterman DA, Karl HW, et al. Adverse sedation events in pediatrics: Analysis of medications used for Sedation. Pediatrics. 2000;106(4):633–644.

4. Cravero JP, Blike GT. Review of pediatric sedation. Anesthesia and Analgesia. 2006;99(5):1355–1364.

5. European Academy of Paediatric Dentistry (EAPD). Guidelines on sedation in paediatric dentistry. In: http://www.eapd.gr/dat/5CF03741/file.pdf;.

6. Goodson JM, Moore PA. Life-threatening reactions after pedodontic sedation: an assessment of narcotic, local anesthetic, and antiemetic drug interaction. Journal of the American Dental Association. 1983;107(2):239–245.

7. 2010. Guidelines on sedation and/or analgesia for diagnostic and interventional medical, dental or surgical procedures. In: http://www.anzca.edu.au/resources/professional-documents/documents/professional-standards/pdf-files/PS9-2010.pdf; 2010.

8. Hosey MT. UK National Clinical Guidelines in Paediatric Dentistry Managing anxious children: the use of conscious sedation in paediatric dentistry. International Journal of Paediatric Dentistry. 2002;12(5):359–372.

9. Houpt M. Project USAP, 2000 – use of sedative agents by pediatric dentists: a 15-year follow up survey. Pediatric Dentistry. 2002;24(4):289–294.

10. Kupietzky A, Houpt MI. Midazolam: a review of its use for conscious sedation of children. Pediatric Dentistry. 1993;15(4):237–241.

11. Lee JY, Vann WF, Roberts MW. A cost analysis of treating pediatric dental patients using general anesthesia versus conscious sedation. Pediatric Dentistry. 2000;22(1):27–32.

12. Primosch RE, Buzzi IM, Jerrell G. Effect of nitrous oxide-oxygen inhalation with scavenging on behavioral and physiological parameters during routine pediatric dental treatment. Pediatric Dentistry. 1999;21(7):417–420.

13. Royal College of Dental Surgeons of Ontario, Canada. Guidelines: use of sedation and general anaesthesia in dental practice. In: http://www.rcdso.org/sedationAnaesthesia_pdf/Guidelines_sedation_06_09.pdf; 2009.

14. Society for the Advancement of Anaesthesia in Dentistry. Standardised evaluation of conscious sedation practice for dentistry in the UK. In: http://www.saad.org.uk/files/documents/Standardised%20Evaluation%20of%20Conscious%20Sedation%20Practice%20for%20Dentistry%20in%20the%20UK.pdf; 2009.

15. Wilson S. Pharmacological management of the pediatric dental patient. Pediatric Dentistry. 2004;26(2):131–136.

16. Yagiela JA, Cote CJ, Notterman DA, et al. Adverse sedation events in pediatrics. Pediatrics. 2001;107(6):1494.