G

GA (tabun), 376
GABA (γ-Aminobutyric acid), 339
GABAA–benzodiazepine receptor complex, 339, 339f
non-benzodiazepine hypnotics, 341
Gabapentin (Neurontin)
adjuvant analgesics, 291
antiepilepsy drugs, 358
dosages, 355t
mode of action, 354
GABA transmission, antiepilepsy drugs, 354, 357–358
GAD See Generalised anxiety disorder (GAD)
Galantamine, 344, 345
Gallstones, 555
hormone replacement therapy, 604
γ-Aminobutyric acid (GABA), 339
γ-Hydroxybutyrate (GHB), 148
Ganciclovir, 221
Ganirelix, 598
Gases, inhalational administration, 88
Gas gangrene, 209
Gastric acid secretion, 528–530, 530f
drugs, 530–531 see also specific drugs
Gastric contents, general anaesthesia, 296
Gastric secretion, histamine actions, 471
Gastrin, 529
Gastroduodenal surgery, 168
Gastrointestinal drugs
anticoagulant drug interactions, 487
breast feeding, 95
Gastrointestinal tract
absorption from, 85–86
adrenal steroid effects, 564
antimuscarinic drug therapy, 380
bleeding, 282
Candida infections, 223
diseases/disorders, 536–544 see also specific diseases/disorders
motility patterns, 537
NSAID adverse effects, 244–245, 282, 529–530
opioid effects, 284
parasympathetic nervous system, 373
surgery, 191 see also specific anatomical features
Gastro-oesophageal reflux disease (GORD), 528
management, 532
Gastroparesis, 544
Gatifloxacin, 209
GB (sarin), 376
GD (soman), 376
Gefitinib (Iressa), 520t, 521
Gelatin, 391
Gels, 262
Gemcitabine, 515
Gemeprost (Cervagem), 613
abortion induction, 613
Gemfibrozil, 449
Gender, adverse drug reactions, 114
General anaesthesia, 295–297
after surgery, 296, 297
historical aspects, 295
obstetric anaesthesia, 308
phases of, 296–297 see also specific phases
before surgery (premedication), 296
during surgery, 296–297 see also specific anaesthetics
Generalised anxiety disorder (GAD), 334–335
treatment, 332t, 335
Generalised pruritus, 263
Generalised seizures, 350
Generic drugs, cost-containment, 19
Generic name, 69, 71
Gene therapy, drug discovery and development, 32
Gene transmission, antimicrobial resistance, 169
Genital tract infections, 200–201
Genital tract surgery, 191
Genitourinary tract, 452–465
antimuscarinic drug therapy, 380
opioid effect, 284
Genome-wide association studies (GWAS), 101–102
Genotoxicity, 33–34
Genotropin, 597
Gentamicin, 181
distribution volume, 90t
half-life, 462t
Germ cells, cytotoxic drugs, 514
Gestrinone, 611
GH See Growth hormone (GH)
GHB (γ-Hydroxybutyrate), 148
Giant cell arthritis, 258
Glands, histamine, 470
Glatiramer acetate, 368
Glaucoma, 564
Glibenclamide, 578–579, 579t
Gliclazide, 578–579, 579t
Glimepiride, 579t
Glivec (imatinib), 520t, 521
Glomerular disease, 461
Glomerular elimination, 94–95
Glucagon
β-adrenoceptor-blocking drug overdose, 408
as antidote, 128t
diabetes drug interactions, 581
Glucocorticoid receptors (GR), 242–243, 243f, 559
mechanism of action, 561f
Glucocorticoids, 244–245
asthma treatment, 474, 477
inhaled, 477
mechanism of action, 561f
mode of action, 242–243, 243f
osteoporosis induction, 257, 257f
rheumatoid arthritis, 257 See also Corticosteroids
Glucose-6-phosphate dehydrogenase deficiency, 504–505
drug-induced, 505t
α-Glucosidase inhibitors, 579t
Glue sniffing, 159
Glutamate, nociception, 279
Glycerol, 539
Glyceryl trinitrate (GTN), 395–396
cocaine therapy, 158
Glycoprotein IIb/IIIa receptors
antagonists, 493–494 see also specific drugs
platelet activation, 492
Glycopyrronium, 381
GnRH See Gonadotrophin releasing hormone (GnRH)
Goitre, 591
Gold, immunomodulation, 253
Gold, Harry, 3
Gonadorelin analogues, 518
Gonadotrophin releasing hormone (GnRH), 598
endometriosis, 611–612
Gonorrhoea, 200–201
pharyngeal, 201
uncomplicated, 200–201
GORD See Gastro-oesophageal reflux disease (GORD)
Goserelin, 512t, 598
prostate cancer, 518
Gout, 255–256
G-protein-coupled receptors, 75
Gramicidin, 190
Gram-negative bacterial infections, 180
Granulocyte colony-stimulating factor (G-CSF), 507–508
Granulocytopenia, 117
Granuloma inguinale, 201
Graves disease, radioiodine (131I), 592
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Graves' ophthalmopathy, 593
Grey baby syndrome, 185
Griseofulvin, 227
Growth hormone (GH), 597–598
diabetes drug interactions, 581
Growth hormone release inhibiting hormone, 597
GRs See Glucocorticoid receptors (GR)
GTN See Glyceryl trinitrate (GTN)
Guillain–Barré syndrome, 369
Guinea worm (Dracunculus medinensis), 237t
Gut transit time, diarrhoea, 537
GWAS (genome-wide association studies), 101–102
Gynaecological surgery, 168