In the United States two organizations, the Advisory Committee on Immunization Practices (ACIP) of the Centers for Disease Control and Prevention and the Committee on Infectious Diseases of the American Academy of Pediatrics, govern the recommendations for immunization policies and procedures. In Canada, recommendations are from the National Advisory Committee on Immunization under the authority of the Minister of Health and Public Health Agency of Canada. The policies of each committee are recommendations, not rules, and they change as a result of advances in the field of immunology. Nurses need to be knowledgeable about the purpose of each organization, view immunization practices in light of the needs of each individual child and the community, and keep informed of the latest advances and changes in policy.
The recommended age for beginning primary immunizations of infants is at birth or within 2 weeks of birth (Figs. 12-13 and 12-14). Children born preterm should receive the full dose of each vaccine at the appropriate chronologic age. A recommended catch-up schedule for children not immunized during infancy is available at the Centers for Disease Control and Prevention website (www.cdc.gov/vaccines/recs/schedules/child-schedule.htm). Table 12-5 describes immunization schedules for Canadian children.
TABLE 12-5
ROUTINE IMMUNIZATION SCHEDULE FOR INFANTS AND CHILDREN: CANADA, 2006
Parentheses imply that these doses may not be required, depending on the age of the child or adult.
aDiphtheria, tetanus, acellular pertussis, and inactivated polio virus vaccine (DTaP-IPV): DTaP-IPV (±Hib) vaccine is the preferred vaccine for all doses in the vaccination series, including completion of the series in children who have received one or more doses of DPT (whole cell) vaccine (e.g., recent immigrants). In schedules A and B, the 4- to 6-yr dose can be omitted if the fourth dose was given after the fourth birthday.
bHaemophilus influenzae type b conjugate vaccine (Hib): The Hib schedule shown is for the Haemophilus b capsular polysaccharide–polyribosylribitol phosphate (PRP) conjugated to tetanus toxoid (PRP-T). For catch up, the number of doses depends on the age at which the schedule is begun. Not usually required past age 5 yr.
cMeasles, mumps, and rubella vaccine (MMR): A second dose of MMR is recommended for children at least 1 mo after the first dose for the purpose of better measles protection. For convenience, options include giving it with the next scheduled vaccination at 18 mo of age or at school entry (4-6 yr) (depending on the provincial/territorial policy) or at any intervening age that is practical. In the catch-up schedule (B), the first dose should not be given until the child is ≥12 mo old. MMR should be given to all susceptible adolescents and adults.
dVaricella vaccine (Var): Children ages 12 mo to 12 yr should receive one dose of varicella vaccine. Susceptible individuals ≥13 yr of age should receive two doses at least 28 days apart.
eHepatitis B vaccine (HB): Hepatitis B vaccine can be routinely given to infants or preadolescents, depending on the provincial/territorial policy. For infants born to chronic carrier mothers, the first dose should be given at birth (with hepatitis B immunoglobulin); otherwise, the first dose can be given at 2 mo of age to fit more conveniently with other routine infant immunization visits. The second dose should be administered at least 1 mo after the first dose, and the third at least 2 mo after the second dose, but these may fit more conveniently into the 4- and 6-mo immunization visits. A two-dose schedule for adolescents is an option.
fPneumococcal conjugate vaccine–7-valent (Pneu–C-7): Recommended for all children <2 yr of age. The recommended schedule depends on the age of the child when vaccination is begun.
gMeningococcal C conjugate vaccine (Men-C): Recommended for children <5 yr of age, adolescents, and young adults. The recommended schedule depends on the age of the individual and the conjugate vaccine used. At least one dose in the primary infant series should be given after 5 mo of age. If the provincial/territorial policy is to give Men-C to persons ≥12 mo of age, one dose is sufficient.
hDiphtheria, tetanus, acellular pertussis vaccine—adult/adolescent formulation (Tdap): A combined adsorbed “adult type” preparation for use in people ≥7 yr of age; contains less diphtheria toxoid and pertussis antigens than preparations given to younger children and is less likely to cause reactions in older people.
iInfluenza vaccine (Inf): Recommended for all children 6-23 mo of age and all persons ≥65 yr of age. Previously unvaccinated children <9 yr of age require two doses of the current season’s vaccine with an interval of ≥4 wk. The second dose within the same season is not required if the child received one or more doses of influenza vaccine during the previous influenza season.
jInactivated polio virus (IPV)
Modified from Public Health Agency of Canada: Canadian immunization guide, ed 7, Ottawa, Ontario, Canada, 2006, The Agency.
Fig. 12-13 Recommended immunization schedule for persons ages 0 through 6 years. *In March 2010 ACIP changed the recommendation for the pneumococcal vaccine; it is now recommended that PCV13 be administered to all children 2 to 59 months of age. PCV13 should replace PCV 7. (From Centers for Disease Control and Prevention: Recommended immunization schedules for persons aged 0 through 18 years—United States, 2010, MMWR 58[51-52]:1-4, 2010.)
Fig. 12-14 Recommended immunization schedule for persons ages 7 through 18 years. (From Centers for Disease Control and Prevention: Recommended immunization schedules for persons aged 0 through 18 years—United States, 2010, MMWR 58[51-52]:1-4, 2010.)
Children who began primary immunization at the recommended age but fail to receive all the doses do not need to begin the series again but instead receive only the missed doses. For situations in which there is doubt that the child will return for immunization according to the optimum schedule, HBV vaccine (HepB), DTaP, IPV (poliovirus vaccine), MMR, varicella, and Hib vaccines can be administered simultaneously. Parenteral vaccines are given in separate syringes in different injection sites (American Academy of Pediatrics, 2009b).
Hepatitis B Virus: HBV is a significant pediatric disease because HBV infections that occur during childhood and adolescence can lead to fatal consequences from cirrhosis or liver cancer during adulthood. Up to 90% of infants infected perinatally and 25% to 50% of children infected before age 5 years become HBV carriers. In addition, the incidence of HBV infection increases rapidly during adolescence (American Academy of Pediatrics, 2009b). It is recommended that newborns receive HepB before hospital discharge if the mother is hepatitis B surface antigen (HBsAg) negative. Monovalent HepB should be given as the birth dose, whereas combination vaccine containing HepB may be given for subsequent doses in the series (see also Fig. 12-13, footnote 1). Both full-term and preterm infants born to mothers whose HBsAg status is positive or unknown should receive HepB and hepatitis B immune globulin (HBIG), 0.5 ml, within 12 hours of birth at two different injection sites. Because the immune response to HepB is not optimum in newborns weighing less than 2000 g (4.4 lb), the first HepB dose should be given to such infants at 1 month, as long as the mother’s HBsAg status is negative (American Academy of Pediatrics, 2009b). In the event that the preterm infant is given a dose at birth, the current recommendation is that the infant be given the full series (three additional doses) at 1, 2, and 6 months of age. The American Academy of Pediatrics (2009b) also encourages immunization of all children by age 11 years.
In the late 1990s HepB contained small amounts of mercury (thimerosal) as a preservative, which generated concern regarding possible mercury poisoning in infants and led to a subsequent decrease in HepB immunization rates in newborns. However, a preservative-free HepB (Recombivax HB, pediatric-adolescent formulation) is available, and the Centers for Disease Control and Prevention (2005a) strongly recommend that HepB immunization occur in newborns before discharge from the birth hospital. To date, studies have not found any association between thimerosal in vaccines and neurologic developmental disorders such as autism spectrum disorder (DeStefano, 2007; Heron, Golding, and ALSPAC Study Team, 2004).
The vaccine is given intramuscularly in the vastus lateralis in newborns or in the deltoid for older infants and children. Regardless of age, avoid the dorsogluteal site because it has been associated with low antibody seroconversion rates, indicating a reduced immune response. No data exist regarding the seroconversion when the ventrogluteal site is used. The vaccine can be safely administered simultaneously at a separate site with DTaP, MMR, and Hib vaccines.
Hepatitis A Virus: Hepatitis A has been recognized as a significant child health problem, particularly in communities with unusually high infection rates. HAV is spread by the fecal-oral route and from person-to-person contact, by ingestion of contaminated food or water, and rarely by blood transfusion. The illness has an abrupt onset, with fever, malaise, anorexia, nausea, abdominal discomfort, dark urine, and jaundice being the most common clinical signs of infection. In children under 6 years of age, who represent approximately one third of all cases of hepatitis A, the disease may be asymptomatic, and jaundice is rarely evident.
HepA vaccine is now recommended for all children beginning at age 1 year (i.e., 12 months to 23 months). The second dose in the two-dose series may be administered no sooner than 6 months after the first dose. Since the implementation of widespread childhood HepA vaccination, infection rates among children ages 5 to 14 years have declined significantly (Centers for Disease Control and Prevention, 2006a). For further information, see Fig. 12-13, footnote 10.
Diphtheria: Although cases of diphtheria are rare in the United States, the disease can result in significant morbidity. Respiratory manifestations include respiratory nasopharyngitis or obstructive laryngotracheitis with upper airway obstruction. The cutaneous manifestations of the disease include vaginal, otic, conjunctival, or cutaneous lesions, which are primarily seen in urban homeless persons and in the tropics (American Academy of Pediatrics, 2009b). Administer a single dose of equine antitoxin intravenously to the child with clinical symptoms because of the often fulminant progression of the disease (American Academy of Pediatrics, 2009b). Diphtheria vaccine is commonly administered (1) in combination with tetanus and pertussis vaccines (DTaP) or DTaP and Hib vaccines for children younger than 7 years of age, (2) in combination with a conjugate H. influenzae type B vaccine (see Fig. 12-13), (3) in a combined vaccine with tetanus (DT) for children younger than 7 years of age who have some contraindication to receiving pertussis vaccine, (4) in combination with tetanus and acellular pertussis (Tdap) for children 11 years and older, or (5) as a single antigen when combined antigen preparations are not indicated. Although the diphtheria vaccine does not produce absolute immunity, protective antitoxin persists for 10 years or more when given according to the recommended schedule, and boosters are given every 10 years for life (see discussion below for adolescent diphtheria and acellular pertussis and tetanus toxoid recommendation). Several vaccines contain diphtheria toxoid (Hib, meningococcal, pneumococcal), but this does not confer immunity to the disease.
Tetanus: Three forms of tetanus vaccine—tetanus toxoid, tetanus immunoglobulin (TIG) (human), and tetanus antitoxin (equine antitoxin)—are available; however, tetanus antitoxin is no longer available in the United States. Tetanus toxoid is used for routine primary immunization, usually in one of the combinations listed for diphtheria, and provides protective antitoxin levels for approximately 10 years.
Tetanus and diphtheria toxoids along with acellular pertussis vaccine (Tdap, adolescent formulation) are now recommended for children ages 11 to 12 years who have completed the recommended DTaP/DTP vaccine series but have not received the tetanus (Td) booster dose. Adolescents 13 to 18 years of age who have not received the Td/Tdap booster should receive a single Tdap booster, provided the routine DTaP/DTP childhood immunization series has been previously received. It is recommended that children receive subsequent Td boosters every 10 years (American Academy of Pediatrics, 2009b) (see Fig. 12-13, footnote 3). Boostrix (Tdap) is currently licensed for children 10 to 18 years of age, whereas Adacel (Tdap) is licensed for individuals 11 to 64 years of age.
For wound management, passive immunity is available with TIG. Persons with a history of two previous doses of tetanus toxoid can receive a booster dose of the toxoid. Separate syringes and different sites are used when tetanus toxoid and TIG are given concurrently. Table 12-6 summarizes the recommended procedure for tetanus prophylaxis in wound management.
Table 12-6
GUIDE TO TETANUS PROPHYLAXIS IN ROUTINE WOUND MANAGEMENT
Td, Adult-type diphtheria and tetanus toxoids; TD, pediatric diphtheria and tetanus toxoids; Tdap, tetanus toxoid, reduced diphtheria toxoid, acellular pertussis; TIG, tetanus immunoglobulin.
aSuch as, but not limited to, wounds contaminated with dirt, feces, soil, and saliva; puncture wounds; avulsions; and wounds resulting from missiles, crushing, burns, and frostbite.
bFor children <7 yr old: DTaP (diphtheria-tetanus–acellular pertussis) (or DT [diphtheria-tetanus], if pertussis vaccine is contraindicated) is preferred to tetanus toxoid alone. For persons >7 yr of age, Td is preferred to tetanus toxoid alone.
cTdap is preferred to Td vaccine for adolescents who never have received Tdap vaccine. Td is preferred to tetanus toxoid (TT) vaccine in adolescents who formerly received Tdap vaccine or when Tdap is not available.
dImmune globulin intravenous should be used when TIG is not available
eIf only three doses of fluid toxoid have been received, then a fourth dose of toxoid, preferably an adsorbed toxoid, should be given. Although licensed, fluid tetanus toxoid is rarely used.
fYes, if ≥10 yr since last tetanus-containing dose.
gYes, if >5 yr since last tetanus-containing dose. (More frequent boosters are not needed and can accentuate side effects.)
Data from American Academy of Pediatrics, Committee on Infectious Diseases, Pickering L, editor: 2009 Red book: report of the Committee on Infectious Diseases, ed 28, Elk Grove Village, Ill, 2009, The Academy.
For children over 7 years who require wound prophylaxis, tetanus immunization may be accomplished by administering Td (adult-type diphtheria and tetanus toxoids). If TIG is not available, the equine antitoxin (not available in the United States) may be administered after appropriate testing for sensitivity. The antitoxin is administered in a separate syringe and at a separate intramuscular site if given concurrently with tetanus toxoid.
Pertussis: Pertussis vaccine is recommended for all children 6 weeks through 6 years of age (up to the seventh birthday) who have no neurologic contraindications to its use. Concerns over outbreaks of the disease in the past decade have prompted discussion about vaccinating infants and adults. Many cases of pertussis have occurred in children less than 6 months or persons over 7 years, both groups falling in the category for which pertussis immunization previously was not recommended (Centers for Disease Control and Prevention, 2005c). The tetanus and diphtheria toxoids and acellular pertussis vaccine (Tdap) is now recommended at ages 11 to 12 years for children who have completed the DTaP/DTP childhood series. The Tdap is also recommended for adolescents 13 to 18 years old who have not received a tetanus booster (Td) or Tdap dose and have completed the childhood DTaP/DTP series. When the Tdap is used as a booster dose, it may be administered 5 years from the last Td dose or earlier if pertussis immunity is necessary (Centers for Disease Control and Prevention, 2009).
Currently, two forms of pertussis vaccine are available in the United States. The whole-cell pertussis vaccine is prepared from inactivated cells of Bordetella pertussis and contains multiple antigens. In contrast, the acellular pertussis vaccine contains one or more immunogens derived from the B. pertussis organism. The highly purified acellular vaccine is associated with fewer local and systemic reactions than those occurring with the whole-cell vaccine in children of similar age. The acellular pertussis vaccine is recommended by the American Academy of Pediatrics (2009b) for the first three immunizations and is usually given at 2, 4, and 6 months of age with diphtheria and tetanus (DTaP). Several forms of acellular pertussis vaccine are currently licensed for use in infants: Daptacel, Pediarix, Kinrix (DTaP and IPV), and Infanrix (diphtheria, tetanus toxoid, and acellular pertussis conjugate). Pentacel is licensed for use in infants 4 weeks old and older; in addition to acellular pertussis, diphtheria, and tetanus, this vaccine also contains inactivated poliovirus (IPV) and Hib conjugate. Either the acellular or whole-cell vaccine may be given for the fourth and fifth doses, but the acellular is preferred. It is also recommended that the first three DTaP vaccinations be from the same manufacturer. The fourth dose may be from a different manufacturer. The child who has received one or more whole-cell vaccines may complete the series of five with the acellular vaccine.
Health care workers who may be susceptible to pertussis as a result of waning immunity and who have potential exposure to children or adults with pertussis should take the necessary protective precautions against droplet contamination (wear procedural or surgical masks and practice hand washing). The diagnosis of pertussis may be missed or delayed in unvaccinated infants, who often are seen with respiratory distress and apnea without the typical cough (Centers for Disease Control and Prevention, 2005c). Additional guidelines for prevention and treatment of pertussis among health care workers and close contacts are given in the 2009 Red Book: Report of the Committee on Infectious Diseases (American Academy of Pediatrics, 2009b).
Polio: An all-IPV (inactivated poliovirus vaccine) schedule for routine childhood polio vaccination is now recommended for children in the United States. All children should receive four doses of IPV at 2 months, 4 months, 6 to 18 months, and 4 to 6 years of age (American Academy of Pediatrics, 2009b).
The change from the exclusive use of oral polio vaccine (OPV) to the exclusive use of IPV is related to the rare risk of vaccine-associated polio paralysis (VAPP) from OPV. The exclusive use of IPV eliminates the risk of VAPP but is associated with an increased number of injections and increased cost. Since IPV usage was instituted in the United States in 2000, no new indigenously acquired cases of VAPP have occurred. Pediarix is a combination vaccine containing DTaP, hepatitis B, and IPV. This may be used as the primary immunization beginning at 2 months of age. Kinrix may be used for the fourth booster dose of IPV and fifth booster dose of DTaP at 4 to 6 years of age (American Academy of Pediatrics, 2009b).
Measles: The measles (rubeola) vaccine is given at 12 to 15 months of age. During the course of measles outbreaks, the vaccine can be given any time after 6 months of age, followed by a second inoculation after age 12 months. The second measles immunization is recommended at 4 to 6 years of age (at school entry) but may be given earlier provided that 4 weeks have elapsed since the administration of the previous dose. Revaccination should occur by 11 to 12 years of age if the measles vaccine was not administered at school entry (4 to 6 years). Any child who is vaccinated before 12 months of age should receive two additional doses beginning at 12 to 15 months and separated by at least 4 weeks (American Academy of Pediatrics, 2009b). Revaccination should include all individuals born after 1956 who have not received two doses of measles vaccine after 12 months of age. Individuals born before this date are thought to be immune from exposure to natural measles virus. Because of the continuing occurrence of measles in older children and young adults, identify potentially susceptible adolescents and young adults and immunize them if two doses of measles vaccine have not been administered previously or the person had a confirmed case of the illness.
The MMRV vaccine (measles, mumps, rubella, and varicella) is an attenuated live virus vaccine and may be given to children 12 months to 12 years of age concurrent with other vaccines. Recent concerns for increased risk of febrile seizures in children 12 months to 23 months of age after administration of MMRV has prompted the ACIP (Centers for Disease Control and Prevention, 2008b) to remove its recommendation for MMRV being the preferred vaccine (versus separate injections of MMR and varicella vaccines) (American Academy of Pediatrics, 2009b).
Vitamin A supplementation has been effective in decreasing the morbidity and mortality associated with measles in developing countries. A Cochrane review of studies wherein a single dose of vitamin A was administered to children with measles found no decrease in mortality. However, children with measles under the age of 2 years who received two doses of vitamin A (200,000 international units) on consecutive days did have decreased mortality rates and a reduced rate of pneumonia-specific mortality (Huiming, Chaomin, and Meng, 2005).
Mumps: Mumps virus vaccine is recommended for children at 12 to 15 months of age and is typically given in combination with measles and rubella. It should not be administered to infants younger than 12 months because persisting maternal antibodies can interfere with the immune response. Because of continued occurrence of the disease, especially in children 10 to 19 years of age, mumps immunization is recommended for all individuals born after 1957 who may be susceptible to mumps (i.e., those who have no history of having had the disease or vaccine and who have no laboratory evidence of immunity).
Rubella: Rubella is a relatively mild infection in children, but in a pregnant woman the actual infection presents serious risks to the developing fetus. Therefore the aim of rubella immunization is actually protection of the unborn child rather than the recipient of the immunization.
Rubella immunization is recommended for all children at 12 to 15 months of age and is administered in a combined form with measles and mumps vaccine. Increased emphasis should also be placed on vaccinating all unimmunized prepubertal children and susceptible adolescents and adult women in the childbearing age-group. Because the live attenuated virus may cross the placenta and theoretically present a risk to the developing fetus, rubella vaccine is currently not given to any pregnant woman. Although this is standard practice, current evidence from women who received the vaccine while pregnant and delivered unaffected offspring indicates that the risk to the fetus is negligible. In addition, there is no reported danger of administering rubella vaccine to a child if the mother is pregnant.
Haemophilus influenzae Type b: Hib conjugate vaccines protect against a number of serious infections caused by Hib, especially bacterial meningitis, epiglottitis, bacterial pneumonia, septic arthritis, and sepsis (Hib is not associated with the viruses that cause influenza, or “flu”). Hib vaccines that are currently available include PedvaxHIB, Pentacel, and Comvax, which are combination vaccines; HibTITER; and ActHIB. Pentacel is described in the previous section on Pertussis. These conjugate vaccines connect Hib to a nontoxic form of another organism, such as meningococcal protein or diphtheria protein. There is no antibody response to these nontoxic proteins, but they significantly improve the antibody response to Hib, especially in infants. The use of combination vaccines provides equivalent immunogenicity and decreases the number of injections an infant receives. However, it is important that they be given to the appropriate-age child.
The 2009 Centers for Disease Control and Prevention immunization guidelines indicate there is limited data for administering the HiB vaccine to persons 5 years and older; however, the guidelines suggest that children with sickle cell disease, leukemia, or human immunodeficiency virus (HIV) infection, or children who have had a splenectomy, may benefit from one dose of the Hib vaccine (Centers for Disease Control and Prevention, 2009).
When possible, the Hib conjugate vaccine used at the first vaccination should be used for all subsequent vaccinations in the primary series. All Hib vaccines are administered by intramuscular injection using a separate syringe and at a site separate from any concurrent vaccinations.
The use of meningococcal and diphtheria proteins in combination vaccines does not mean the child has received adequate immunization for meningococcal or diphtheria illnesses. The child must be given the appropriate vaccine for that specific disease.
Varicella: Administration of the cell-free live-attenuated varicella vaccine is recommended for any susceptible child (one who lacks proof of varicella vaccination or has a reliable history of varicella infection). A single dose of 0.5 ml should be given by subcutaneous injection. The first dose of varicella vaccine is recommended for children ages 12 to 15 months, and to ensure adequate protection a second varicella vaccine is recommended for children at 4 to 6 years of age. The second varicella vaccine may be administered before 4 years of age as long as a period of 3 months occurs between the first and second doses. Children 13 years of age or older who are susceptible should receive two doses administered at least 4 weeks apart. Children in the same age-group who have received only one previous varicella vaccine should receive a second varicella vaccine. MMRV is not licensed for use in children ages 13 years or older (American Academy of Pediatrics, 2009b). The American Academy of Pediatrics (2009b) reports that the two-dose regimen was adopted to protect children who did not have adequate protection with one dose, not because of waning immunity to the vaccine.
According to the American Academy of Pediatrics (2009b), children who have received two doses of the varicella vaccine are one third less likely to have breakthrough illness in the first 10 years of immunization in comparison with those who have received one dose. Children who do contract varicella after immunization reportedly have milder cases with fewer vesicles, lower degree of fever, and faster recovery. Antibodies persist for at least 8 years (American Academy of Pediatrics, 2009b).
Keep the vaccine frozen in the lyophilic form (stable particles that readily go into solution) and use it within 30 minutes of being reconstituted to ensure viral potency.
Varicella vaccine may be administered simultaneously with MMR. However, separate syringes and injection sites should be used. If they are not administered simultaneously, the interval between administration of varicella vaccine and MMR should be at least 1 month. Varicella vaccine may also be given simultaneously with DTaP, IPV, HepB, or Hib (American Academy of Pediatrics, 2009b).
Pneumococcal: A seven-valent Streptococcus pneumoniae conjugate vaccine (PCV7, or Prevnar) has been used for children under 2 years of age since 2000. In February 2010 the Food and Drug Administration approved a new 13-valent pneumococcal vaccine, Prevnar 13, which replaces PCV7 (Prevnar). PCV13 was approved for children 6 weeks to 71 months of age (Centers for Disease Control and Prevention, 2010). Streptococcal pneumococci are responsible for a number of bacterial infections in children under 2 years, which may cause serious morbidity and mortality. Among these are generalized infections such as septicemia and bacterial meningitis or localized infections such as otitis media, sinusitis, and pneumonia. These illnesses are particularly problematic in children who attend daycare facilities (the incidence in daycare children is two to three times higher than in children not attending out-of-home daycare) and in those who are immunocompromised.
The vaccine is administered at 2, 4, and 6 months, with a fourth dose at 12 to 15 months of age. Children 7 to 11 months old may receive three doses as long as they are 6 to 8 weeks apart and a fourth dose at 12 to 15 months. Children 12 to 23 months who have not been immunized with the pneumococcal vaccine may be given two doses, 6 to 8 weeks apart. PCV13 is also recommended for all children under 24 months and in older children (24 to 71 months) with sickle cell disease; functional or anatomic asplenia; nephrotic syndrome or chronic renal failure; conditions associated with immunosuppression, such as solid organ transplantation, drug therapy, or cytoreduction therapy (including long-term systemic corticosteroid therapy); diabetes mellitus; cochlear implants; congenital immunodeficiency; HIV infection; cerebrospinal fluid leaks; chronic cardiovascular disease (e.g., congestive heart failure or cardiomyopathy); chronic pulmonary disease (e.g., emphysema or cystic fibrosis, but not asthma); chronic liver disease (e.g., cirrhosis); or exposure to living environments or social settings in which the risk of invasive pneumococcal disease or its complications is very high (e.g., Alaskan Native, African-American, and certain Native American populations) (American Academy of Pediatrics, 2009b). Low-birth-weight infants (≤1500 g [3.3 lb]) should receive the vaccine when they reach a chronologic age of 6 to 8 weeks regardless of calculated gestational age. The PCV7 vaccine may be administered in conjunction with all other immunizations in a separate syringe and at a separate intramuscular site.
The PPV (pneumococcal polysaccharide [23-valent] vaccine) is not recommended for children younger than 24 months who do not have one of the high-risk conditions described previously.
Influenza: The influenza vaccine is now recommended annually for children 6 months to 18 years. Influenza vaccine (trivalent inactivated influenza vaccine [TIV]) may be given to any healthy children 6 months old and older. Children who have a reported anaphylactic hypersensitivity to eggs should not receive the vaccine. The vaccine is administered in early fall before the flu season begins and is repeated yearly for ongoing protection. The intramuscular vaccine is administered as two separate doses 4 weeks apart in first-time recipients under the age of 9 years. The dose is 0.25 ml for children ages 6 to 35 months and 0.5 ml for children 3 years and above. The vaccine may be given simultaneously with other vaccines but at a separate site. The vaccine is administered yearly because different strains of influenza are used each year in the manufacture of the vaccine.
The live attenuated influenza vaccine (LAIV) is an acceptable alternative to the intramuscular trivalent vaccine in specific age-groups. The vaccine is given nasally as two doses at least 28 days apart in healthy persons ages 2 to 49 years. Although it is an alternative to the injection, it costs more and may not be covered by insurance companies. Either TIV or LAIV may be given to healthy, nonpregnant persons ages 2 to 49 years (American Academy of Pediatrics, 2009c). Yearly influenza vaccine should be administered to health care workers and to children ages 6 to 59 months with medical conditions (including asthma, cardiac disease, HIV, diabetes, and sickle cell disease) that place them at risk for influenza-related complications.
The H1N1 virus (swine flu) is a subtype of influenza type A. Previous outbreaks of H1N1 influenza occurred in 1918, and the mortality rates were significant both in the United States and worldwide (American Academy of Pediatrics, 2009b). The pandemic of H1N1 caused significant morbidity and mortality worldwide, but particularly in Mexico and the United States. Antigenic shift occurs when influenza A viruses undergo significant changes that result in new infection subtypes; such is the case in the current pandemic. The signs and symptoms of H1N1 flu are the same as those mentioned below for influenza. Oseltamivir (Tamiflu) has been approved for infants 3 months of age and older who are symptomatic and in infants 0 to 3 months if the practitioner feels it is absolutely critical to the child’s well being. In the United States the 2011-2012 winter influenza vaccines (LAIV and TIV) contain protection against the H1N1 influenza strain as well as other influenza strains. The most updated information on the status of this disease may be found at the websites for the Centers for Disease Control and Prevention (www.cdc.gov) and the World Health Organization (www.who.int/csr/disease/swineflu/en/index.html).
Meningococcal: Invasive meningococcal disease continues to be the cause of high morbidity in children in the United States. Infants younger than 1 year of age are particularly susceptible, yet the highest fatalities occur in adolescents (approximately 20%). There is also evidence that the risk of meningococcal infections is high in college freshmen living in dormitories. Meningococcal infections are also responsible for significant morbidities, including limb or digit amputation, skin scarring, hearing loss, and neurologic disabilities (American Academy of Pediatrics, 2009b).
Neisseria meningitidis is the leading cause of bacterial meningitis in the United States. It is now recommended that children 2 to 10 years old at increased risk for meningococcal disease receive either the quadrivalent conjugate vaccine MCV4 (Menactra) or MenACY-CRM (Menveo). Adolescents who received a single meningococcal vaccine prior to the age of 16 years should receive a single booster of meningococcal quadrivalent vaccine (Centers for Disease Control and Prevention, 2011). Children in certain high-risk groups such as those with terminal complement component deficiency, anatomic or functional asplenia, or HIV and children who travel to or reside in countries where N. meningitidis is hyperendemic or epidemic should also receive one of the quadrivalent meningococcal vaccines (American Academy of Pediatrics, 2009b). Children and adolescents 11 to 18 years of age should receive a single immunization of MCV4. Others at high risk who should receive MCV4 include college freshmen living in dormitories and military recruits (American Academy of Pediatrics, 2009b).
Persons who are at high risk for the disease and previously received MPSV4 3 or more years previously should be vaccinated with MCV4. The vaccine protects against meningococcal disease caused by serogroups A, C, Y, and W-135. MCV4 is administered as an intramuscular injection (0.5 ml) and may be administered in conjunction with other vaccines in a separate syringe and at a separate site. Immunization with MCV4 is contraindicated in persons with hypersensitivity to any components of the vaccine, including diphtheria toxoid, and to rubber latex (part of vial stopper).
Reports of an association between MCV4 (Menactra) and cases of Guillain-Barré syndrome in vaccinated persons ages 11 to 19 years of age have been addressed. Onset of symptoms occurred within 2 to 23 days of vaccination. A preliminary survey by the Centers for Disease Control and Prevention (2006b) indicates there are insufficient data to change the 2005 recommendation for adolescents, college freshmen residing in dormitories, and other high-risk populations.
Two additional vaccines are recommended for children and adolescents at high risk for particular diseases. Two rotavirus vaccines, RotaTeq and Rotarix, have been licensed by the U.S. Food and Drug Administration for distribution in the United States. Rotavirus is one of the leading causes of severe diarrhea in infants and young children. RotaTeq is licensed for administration to infants at 6 to 12 weeks of age, with two additional doses administered at 4- to 10-week intervals but not after 32 weeks of age. The dose is 2 ml, and the product must be protected from light until administration (American Academy of Pediatrics, 2009b). Rotarix (1 ml) may be administered beginning at 6 weeks of age with a second dose at least 4 weeks after the first dose, but before 24 weeks of age. Both vaccines are administered orally.
A quadrivalent human papillomavirus (HPV) vaccine, Gardasil, has been approved and is recommended for female children and adolescents to prevent HPV-related cervical cancer. The vaccine is administered intramuscularly in three separate doses; the first dose in the series may be given at 11 to 12 years of age (minimum age 9 years), the second dose is administered 2 months after the first, and the third dose is given 6 months after the first dose (Centers for Disease Control and Prevention, 2007b). (See Fig. 12-14, footnote 2.)
Immunizations that may be used in older children and adolescents in the future and that are being evaluated include vaccines for preventing diseases such as herpes simplex virus, human cytomegalovirus, and Epstein-Barr virus. Others, such as the rabies vaccine, are discussed elsewhere in this text.
Vaccines for routine immunizations are among the safest and most reliable drugs available. However, minor side effects do occur after many of the immunizations, and, rarely, a serious reaction may result from the vaccine. A number of inactive components are incorporated in vaccines to enhance their effectiveness and safety. Some of these components include preservatives, stabilizers, adjuvants, antibiotics (e.g., neomycin), and purified culture medium proteins (e.g., egg) to enhance effectiveness. A child may react to the preservative in the vaccine rather than the vaccine component; an example of this is the hepatitis B vaccine, which is prepared from yeast cultures. Yeast hypersensitivity therefore would preclude one from receiving that particular vaccine without consulting an allergist. Trace amounts of neomycin are used to decrease bacterial growth within certain vaccine preparations, and persons with documented anaphylactic reactions to neomycin should avoid those vaccines. Most vaccine preparations now contain vial stoppers with a synthetic rubber to prevent latex allergy reactions. In the event that an individual has a severe reaction to a vaccine and subsequent immunizations are required, an allergist may be consulted to determine the best course of action.
Some vaccines contain a preservative, thimerosal, which contains ethylmercury. Concerns regarding possible mercury poisoning in the 1990s prompted many to put off vaccination of infants and small children for fear of childhood developmental problems such as autism. A number of manufacturers have since stopped producing vaccines containing thimerosal. No local hypersensitivity reactions to thimerosal have been recorded, and studies on thimerosal and the potential link to autism or any other pervasive developmental disorder failed to establish a causal relationship between the two (DeStefano, 2007; Hviid, Stellfeld, Wohlfahrt, et al, 2003; Parker, Schwartz, Todd, et al, 2004). The Institute of Medicine (2004), following an in-depth 3-year study, issued a report concluding that there is no link between autism and the MMR vaccine or vaccines containing the preservative thimerosal. The H1N1 vaccines do not contain any additives such as thimerosal.
With inactivated antigens, such as DTaP, side effects are most likely to occur within a few hours or days of administration and are usually limited to local tenderness, erythema, and swelling at the injection site; low-grade fever; and behavioral changes (drowsiness, fretfulness, eating less, prolonged or unusual cry). Local reactions tend to be less severe when a needle of sufficient length to deposit the vaccine in the muscle is used (see Atraumatic Care box). Rarely, more severe reactions may occur, especially with pertussis and varicella. Reactions to DTaP tend to be more severe if they occurred with a previous immunization.
Hib vaccine is one of the safest vaccines available but may be associated with low-grade fever and mild local reactions at the site of injection, which resolve rapidly.
Unlike the inactivated antigens, live attenuated virus vaccines such as MMR multiply for days or weeks, and unfavorable reactions and vaccine-associated disorders can occur up to 30 to 60 days later. These reactions are usually mild, although reactions to rubella tend to be more troublesome in older children and adults.
Nurses need to be aware of the reasons for withholding immunizations—both for the child’s safety in terms of avoiding reactions and for the child’s maximum benefit from receiving the vaccine. Unfounded fears and lack of knowledge regarding contraindications can needlessly prevent a child from gaining protection from life-threatening diseases. Issues that have surfaced regarding vaccines include the misconception that administering combination vaccines may overload the child’s immune system. The combined vaccines have undergone rigorous study in relation to side effects and immunogenicity rates following administration. Give parents appropriate information regarding vaccine safety, benefits, and risks so they can make informed decisions regarding vaccinations for their children. The advantage of widespread information on television and the Internet is that it is readily available at any given moment. The disadvantage is that some of this information may be incorrect, incomplete, or misleading and may influence parents to make decisions that could harm their children’s health. Parents may also receive information regarding vaccines from antivaccine groups, which advocate changes in the mass vaccination system in the United States. At times such groups may publicize information related to extremely rare events occurring after a child is immunized.
The general contraindication for all immunizations is a severe febrile illness. This precaution avoids adding the risk of adverse side effects from the vaccine to an already ill child or mistakenly identifying a symptom of the disease as having been caused by the vaccine. The presence of minor illnesses such as the common cold is not a contraindication. Live virus vaccines are generally not administered to anyone with an altered immune system, since multiplication of the virus may be enhanced, causing a severe vaccine-induced illness.
Another contraindication to live virus vaccines (MMR and varicella) is the presence of recently acquired passive immunity through blood transfusions, immunoglobulin, or maternal antibodies. Administration of MMR and varicella should be postponed for a minimum of 3 months after passive immunization with immunoglobulins and blood transfusions (except washed RBCs, which do not interfere with the immune response). Suggested intervals between administration of immunoglobulin preparations and MMR and varicella depend on the type of immune product and dosage. If the vaccine and immunoglobulin are given simultaneously because of imminent exposure to disease, the two preparations are injected at sites far from each other. Vaccination should be repeated after the suggested intervals unless there is serologic evidence of antibody production.
Pregnancy is a contraindication to MMR vaccines, although the risk of fetal damage is primarily theoretic. Breast-feeding is not a contraindication for any vaccine.
A final contraindication is a known allergic response to a previously administered vaccine or a substance in the vaccine. MMR vaccines contain minute amounts of neomycin; measles and mumps vaccines, which are grown on chick embryo tissue cultures, are not believed to contain significant amounts of egg cross-reacting proteins. Therefore only a history of anaphylactic reaction to neomycin, gelatin, or the vaccine itself is considered a contraindication to their use. To identify the rare child who may not be able to receive the vaccines, take a careful allergy history. (See Nursing Care Guidelines box, “Taking an Allergy History,” Chapter 6.) If the child has a history of anaphylaxis, report this to the practitioner before administering the vaccine. Contact dermatitis in reaction to neomycin is not considered a contraindication to immunization. Evidence indicates that children who are egg-sensitive are not at increased risk for untoward reactions to MMR vaccine. Furthermore, skin testing of egg-allergic children with vaccine has failed to predict immediate hypersensitivity reactions (American Academy of Pediatrics, 2009b).
A family history of seizures, allergies to duck meat or duck feathers, and a family history of SIDS are not considered contraindications to receiving childhood vaccines (American Academy of Pediatrics, 2009b).
Nurses are at the forefront in providing parents with appropriate information regarding childhood immunization benefits, contraindications, and side effects and the effects of nonvaccination on the child’s health. Some suggestions for communicating with parents about the benefits of immunizations in childhood include (portions adapted from Coyer, 2002; Fredrickson, Davis, and Bocchini, 2001; Rosenthal, 2004):
• Provide accurate and user-friendly information on vaccines (the necessity for each one, the disease each prevents, potential adverse effects).
• Realize that the parent is expressing concern for the child’s health.
• Acknowledge the parent’s concerns in a genuine, empathetic manner.
• Be knowledgeable about the benefits of individual vaccines, the common adverse effects, and how to minimize those effects.
• Give the parent the vaccine information statement (VIS) beforehand and be prepared to answer any questions that may arise.
• Help the parent make an informed decision regarding the administration of each vaccine.
• Be flexible and provide parents options regarding the administration of multiple vaccines, especially in infants, who must receive multiple injections at 2, 4, and 6 months (i.e., allow parents to space the vaccinations at different visits to decrease the total number of injections at each visit; make provisions for office visits for immunization purposes only [does not incur a practitioner fee except for administration of vaccine], provided the child is healthy).
• Involve the parent in minimizing the potential adverse effects of the vaccine (e.g., administering an appropriate dose of acetaminophen 45 minutes before administering the vaccine [as warranted]; applying a topical analgesic such as lidocaine-prilocaine [EMLA] or 4% lidocaine [LMX4] to the injection sites before going to the administration site [see Atraumatic Care box, p. 505]; following up to check on the child if untoward reactions have occurred in the past or parent is especially anxious about the child’s well-being).
The principal precautions in administering immunizations include proper storage of the vaccine to protect its potency and institution of recommended procedures for injection. The nurse must be familiar with the manufacturer’s directions for storage and reconstitution of the vaccine. For example, if the vaccine is to be refrigerated, it should be stored on a center shelf, not in the door, where frequent temperature increases from opening the refrigerator can alter the vaccine’s potency. For protection against light the vial can be wrapped in aluminum foil. Periodic checks are established to ensure that no vaccine is used after its expiration date.
The DTP (or DTaP) vaccines contain an adjuvant to retain the antigen at the injection site and prolong the stimulatory effect. Because subcutaneous or intracutaneous injection of the adjuvant can cause local irritation, inflammation, or abscess formation, excellent intramuscular injection technique must be used (see Atraumatic Care box, p. 505).
The total series requires several injections, and every attempt is made to rotate the sites and administer the injections as painlessly as possible. (See discussion on intramuscular injections, Chapter 27.) When two or more injections are given at separate sites, the order of injections is arbitrary. Some practitioners suggest injecting the less painful one first. Some believe this is DTP (or DTaP), whereas others suggest the MMR or Hib vaccine. Still others advocate injecting at two sites simultaneously (requires two operators) (see Research Focus box).
Because allergic reactions can occur after injection of vaccines, take the appropriate precautions. (See Nursing Alert on anaphylactic reaction, Chapter 36.)
One of the most important features of injecting vaccines is adequate penetration of the muscle for deposition of the drug intramuscularly, not subcutaneously. In two studies, the use of longer needles in administering vaccines to a group of infants significantly decreased the incidence of localized edema and tenderness (Diggle and Deeks, 2000; Diggle, Deeks, and Pollard, 2006) (see Evidence-Based Practice box).
Because nurses often administer vaccines, they may have the responsibility for adequately informing parents of the nature, prevalence, and risks of the disease; the type of immunization product to be used; the expected benefits and risk of side effects of the vaccine; and the need for accurate immunization records. Referring to immunizations as “baby shots” and limiting the discussion to vague statements about the vaccines are unacceptable practices.
Another important nursing responsibility is accurate documentation. Each child should have an immunization record for parents to keep, especially for families who move frequently. Although immunization rates have increased significantly, health professionals should use every opportunity to encourage complete immunization of all children (see Community Focus box). Blank immunization records may be downloaded from a number of websites, including the Immunization Action Coalition (www.immunize.org), which has vaccine information and records in a number of languages.
Document the following information on the medical record: day, month, and year of administration; manufacturer and lot number of vaccine; and name, address, and title of the person administering the vaccine. Additional data to record are the site and route of administration and evidence that the parent or legal guardian gave informed consent before the immunization was administered. Report any adverse reactions after the administration of a vaccine to the Vaccine Adverse Event Reporting System (www.vaers.hhs.gov; 800-822-7967).
An additional source of vaccine information that must be given to parents (as required by the National Childhood Vaccine Injury Act, 1986) before the administration of vaccines is the VIS for the particular vaccine being administered. Practitioners are required by law to fully inform families of the risks and benefits of the vaccines. VISs are designed to provide updated information to the adult vaccinee or parents or legal guardians of children being vaccinated regarding the risks and benefits of each vaccine. The practitioner should answer questions regarding the information in the VISs. VISs are available for the following vaccines: anthrax, tetanus, diphtheria, pertussis, MMR, IPV, HPV, varicella, Hib, H1N1 influenza, influenza, meningococcal, pneumococcal, rabies, rotavirus, shingles, smallpox, yellow fever, Japanese encephalitis, typhoid, and hepatitis A and B. An updated VIS should be provided to the primary caregiver, and documentation in the patient’s chart should include the VIS title and the VIS publication date. VISs are available from state or local health departments, the Immunization Action Coalition (www.immunize.org/vis), and the Centers for Disease Control and Prevention (http://www.cdc.gov/vaccines/pubs/vis/default.htm; 800-232-4636).
In response to the concerns of manufacturers, practitioners, and parents of children with serious vaccine-associated injuries, the National Childhood Vaccine Injury Act of 1986 and the Vaccine Compensation Amendments of 1987 were passed. These laws are designed to provide fair compensation for children who are inadvertently injured and provide greater protection from liability for vaccine manufacturers and providers. (See American Academy of Pediatrics, 2009b, for further details of this program.)
Bioterrorism and Vaccines: A number of events, including those of September 11, 2001, have precipitated changes in family’s lives across the United States. The threats of anthrax and smallpox germ warfare have prompted public safety and health care officials to reevaluate disasters and threats to the general population’s health. Children are aware of media stories discussing potential threats and may have concerns and fears regarding their personal, family’s, and friends’ safety and health. A common theme expressed among adolescents after the September 11 attack and various wide-scale shootings in high schools was concern and fear for personal safety and the general fear of the unknown outcome in the event of another attack in their community or school.
Nurses are in a position to help families deal effectively with children’s fears and concerns related to events that may affect their mental and physical health. It is not within the scope of this text to discuss the many strategies for counseling children about natural and man-made disasters, but it is important to be knowledgeable about health issues related to vaccines should an event occur that requires wide-scale inoculation of children and adults.
The American Academy of Pediatrics offers a number of resources regarding disasters (www.aap.org/disasters/resources.cfm), including a free Family Readiness Kit that may help parents discuss disaster issues with children (www.aap.org/family/frk/frkit.htm). Starr (2002) provides a number of strategies for helping children of different ages cope with disaster and numerous excellent resources for parents and nurses helping children.
Nurses working with children may use these resources and others to help families and children become knowledgeable about disasters and vaccines developed for the protection of children and adults in the event of exposure to toxic agents.
Injuries are a major cause of death during infancy, especially for children 6 to 12 months old. According to some surveys (Agran, Anderson, Winn, et al, 2003; Pickett, Streight, Simpson, et al, 2003), the leading causes of injury to infants are falls, ingestion injuries (poison and medications), and burns. In a Canadian survey (Pickett, Streight, Simpson, et al, 2003), the top leading causes of injury to infants were falls, ingestion injuries, and burns. The three leading causes of accidental death injury in infants in the United States were suffocation, motor vehicle–related accidents, and drowning (Centers for Disease Control and Prevention, 2007a). Mack, Gilchrist, and Ballesteros (2007) report that fall-related injuries in the home were the most common reason for emergency department visits in infants ages 0 to 12 months; according to these authors one infant is injured every
minutes. In a similar study of infants treated for accidents, the bed was commonly listed as being involved, whereas car seat at 2 months of age and stairs at 12 months were reported to be the cause of the accidental injury (Mack, Gilchrist, and Ballesteros, 2008). Constant vigilance, awareness, and supervision are essential as the child gains increased locomotor and manipulative skills that are coupled with an insatiable curiosity about the environment. Box 12-6 lists the major developmental achievements of each period during infancy and the appropriate injury prevention plan.
Critical Thinking Exercise—Infant Safety
Asphyxiation by foreign material in the respiratory tract, combined with mechanical suffocation, is one of the leading causes of fatal injury in children younger than 1 year. Both food and nonfood items are among the most common foreign bodies ingested and found in the gastrointestinal tract (Agran, Anderson, Winn, et al, 2003). The size, shape, and consistency of foods or objects are important determinants of fatal obstruction. For example, small spheric or cylindric and pliable objects (<3.2 cm [1.2 inches]) are more likely to completely obstruct the airway.
Toys are the most common cause of aspiration; therefore all toys must be carefully inspected for potential danger. Many toys that make noise or rattle, for example, have small beads inside. A broken or cracked toy can be dangerous because the beads can easily be aspirated while the infant has the toy in the mouth. Stuffed animals are potentially dangerous if any of the parts, such as the eyes or nose, are removable buttons or plastic pieces. Front buttons on infant clothes can easily be pulled off and swallowed. An active infant can grab a low-hanging mobile and quickly chew off a small piece. As soon as the infant crawls or plays on the floor, the floor must be kept free of any small articles that can be picked up and swallowed, such as coins and buttons.
Food items are the second most common cause of aspiration, and the most common offenders are hot dogs, candy, nuts, and grapes. When new foods are given to the child, nuts, hard candies, marshmallows, large amounts of peanut butter, or fruits with pits or seeds are avoided. If given to young children, hot dogs must be cut into small, irregular pieces rather than served whole or sliced into sections because their size (diameter), round shape, and consistency allow for complete occlusion of the airway. Perhaps the most dangerous foods are dried beans, which, if aspirated, enlarge when they come in contact with the wet mucosa and block the airway.
Pacifiers can also be dangerous because the entire object may be aspirated if it is small, or the nipple and shield may become detached from the handle and become lodged in the pharynx. Improvised pacifiers, such as those made from a padded nipple, also present dangers. The nipple may separate from the plastic collar and be aspirated. Thus only safe commercial pacifiers should be used, if at all. Candy pacifiers pose dangers because the candy portion can dislodge from the circular base and be aspirated. To be safe, pacifiers should have:
• Sturdy, one-piece construction with material that is nontoxic, flexible, and firm but not brittle
• A mouthguard that cannot be separated from the nipple, has two ventilating holes, and is too large to be aspirated
• No detachable ribbon or string
• A label warning against tying the pacifier around the infant’s neck
Using a syringe to accurately measure and dispense oral liquid medications to young children has become common practice. However, a syringe with a cap becomes a potential aspiration hazard. The newer medication administration syringes for children do not have a removable cap. Other items that can easily be aspirated include soda and fruit juice bottle tops or caps, aluminum soda can pop-top rings that tear off easily, and small key rings (<1.5 inches in diameter).
According to one survey, accidental suffocation and strangulation rates among infants quadrupled between 1984 and 2004 in the United States; African-American boys under the age of 4 months were most affected (Shapiro-Mendoza, Kimball, Tomashek, et al, 2009). Schnitzer (2006) indicates that almost 67% of injury deaths in infants are due to suffocation. Mechanical suffocation includes suffocation by covering of the airway (i.e., mouth and nose); by pressure on the throat and chest; and by exclusion of air, such as by refrigerator entrapment. Nonfood items cause the majority of deaths in young children. Latex balloons, whether partially inflated, uninflated, or popped, are the leading cause of pediatric choking deaths from children’s products. They should be kept away from infants and young children.
The bed or crib poses a number of hazards. An infant who is placed in a bed under tucked-in blankets and sheets can be caught under them and unable to wriggle free. (See Sudden Infant Death Syndrome, Chapter 13.) Bumper crib pads are a common cause of death in infants either as a result of suffocation or strangulation on the bumper ties (Thach, Rutherford, and Harris, 2007). Baby pillows filled with plastic foam beads that make them resemble small bean bags are dangerous; very young infants are suffocated when the pillow contours to the face and blocks the airway. There are potential dangers in adults sleeping with an infant because of the possibility of their rolling over and smothering the child (overlaying), especially when alcohol, tobacco, or recreational drugs are involved. According to U.S. federal regulations, the distance between crib slats should not be more than 6 cm (2.375 inches), roughly the width of three adult fingers. Mattresses should fit snugly against the slats; bumper pads are no longer recommended. A general rule is that the mattress is too small if two adult fingers can be placed between the mattress and crib or bed side. A temporary solution is to place large, rolled towels in the space to create a snug fit.
Corner post extensions on cribs are another source of strangulation. Children have died when their clothing caught on raised corner posts as they climbed out of the crib. Voluntary manufacturing standards state that corner post extensions not exceed inch. However, the safety of any extension is questionable. Decorative extensions need to be removed from cribs. Ideally, information regarding correct crib design should be given prenatally, before parents have purchased or borrowed a crib.*
Mesh-sided playpens and cribs can result in death if the sides are left in the lowered position. Infants have suffocated when they fell off the edge of the mattress and the head or chest was compressed between the floorboard and mesh side. Cribs should be located away from windows, where drape or blind cords can become wrapped around the infant’s neck.
Another cause of suffocation is plastic bags. Large plastic bags used over garments are lightweight and can easily and quickly be wrapped around the head of an active infant or pressed against the face. For this reason, pillows and mattresses should not be covered with plastic. Older infants may play with a plastic bag and accidentally pull it over their heads. Because plastic is nonporous, suffocation occurs in a matter of minutes.
Cords located near the infant or tied around the infant’s neck can potentially cause strangulation. Bibs are removed after meals, and objects such as pacifiers are never hung on a string around the infant’s neck. This is a common practice in some cultures that can be remedied by tying a short string to a pacifier and pinning the string to the child’s shirt.
Toys that have strings attached, such as a telephone, or toys that are tied to cribs or playpens can be hazards because the string can become wrapped around the child’s neck or the child can become entrapped in the toy. As a precaution, all cords should be less than 30 cm (12 inches) long. Crib toys should be hung high enough that the infant cannot become entangled in them and should no longer be used once the child is able to reach them.
Automobile injuries are the leading cause of accidental death in children between the ages of 1 and 9 years (Centers for Disease Control and Prevention, 2007a). A significant number of nonfatal vehicle-related injuries in children between 1 and 4 years of age occur as a result of back-over while children are playing in a driveway (Centers for Disease Control and Prevention, 2005b). In addition, a significant number of infants are injured or die from improper restraint within the vehicle, most often from riding on the lap of another occupant. Desapriya, Joshi, Subwarzi, and colleagues (2008) found that falls accounted for a significant proportion of injuries (98%) in infants from birth to 4 months of age as a result of inappropriate use of a car restraint system. Reports indicate that child restraint use decreases with increasing age of children and increasing number of occupants. Lack of proper child restraint continues to be a major factor in fatal accidents involving children. All infants must be secured in a federally approved restraint rather than held or placed on the seat of the car. There is no safe alternative.
Infant restraints are designed either as an infant-only model or as a convertible infant-toddler model. Either restraint is a semireclined seat that faces the rear of the car. A rear-facing car seat provides the best protection for the disproportionately heavy head and weak neck of an infant (Fig. 12-15). This position minimizes the stress on the neck by spreading the forces of a frontal crash over the entire back, neck, and head; the spine is supported by the back of the car seat. If the seat were faced forward, the head would whip forward because of the force of the crash, creating enormous stress on the neck. A recent study indicated that children 0 to 3 years of age riding properly restrained in the middle of the back seat had a 43% lower risk of injury than children riding in the outboard (window) seat during a crash (Kallan, Durbin, Arbogast, et al, 2008). Another study showed that children 0 to 23 months riding in a rear-facing restraint were less likely to be injured than those riding in a forward-facing restraint (Henary, Sherwood, Crandall, et al, 2007).
Fig. 12-15 Rear-facing infant seat in rear seat of car. (Courtesy Brian and Mayannyn Sallee, Las Vegas.)
The restraint is anchored to the vehicle with the vehicle’s seat belt, and the restraint has a harness system for securing the infant. Some harness systems require a clip to keep the shoulder straps correctly positioned. Newer vehicles (manufactured after 1999) have tether straps that attach to anchors in the car seat to better secure the seat and minimize forward movement of the forward-facing convertible seats in the event of an accident. The LATCH (lower anchor and tether for children) system provides car seat anchors between the front cushion and backrest so that the seat belt does not have to be used. Some automobiles have tether straps for rear-facing infant-only seats as well. (See Chapter 14.) Although many infant restraints can be recliners, they are used in the car only in the position specified by the manufacturer.
It is now recommended that all infants and toddlers ride in a rear-facing car safety seat until they have reached the age of 2 years or they reach the highest weight or height recommended by the car seat manufacturer (American Academy of Pediatrics, 2011).
Rear-facing infant safety seats must not be placed in the front seats of cars equipped with an air bag on the passenger side. If an infant safety seat is placed in the passenger seat with an air bag, the child could be seriously injured if the air bag is released, since rear-facing infant seats extend closer to the dashboard. Severe injuries and deaths in children have occurred from air bags deploying on impact in the front passenger seat. The back seat is the safest area of the car. If the back seat is not an option, an infant restraint may be positioned in the front seat provided that the seat belt can be locked into position and there is no passenger-side air bag. If there is a passenger-side air bag and the child has special health care needs or constant observation is recommended by the practitioner and no other adult is available to ride in the back seat with the child, an on/off switch may be installed to prevent the air bag from deploying and injuring the child riding in the front seat. In vehicles without a back seat, it is best to place the front passenger seat as far back as possible and use appropriate child safety restraint. The new, “smart” air bags include features that make it possible to deactivate the air bag temporarily if an infant must ride in the front seat. Remind parents to reactivate the airbag once the infant is no longer riding in the front seat.* (See discussion of air bag safety in Chapter 14.)
For restraints to be effective, they must be used properly. Dressing the infant in an outfit with sleeves and legs allows the harness to hold the child securely in the seat. A small blanket or towel rolled tightly can be placed on either side of the head to minimize movement and keep the infant’s hips against the back of the seat. Padding between the infant’s legs and crotch can prevent slouching. Thick, soft padding is not placed under the infant or behind the back because during the impact the padding will compress, leaving the harness straps loose. Preterm infants being discharged home should be secured in an appropriate car seat restraint as it would be placed in the car and the infant’s oxygen saturations monitored for a determined period to detect any potential problems with airway occlusion. (For further discussion of car seat restraints, see Chapter 14; for preterm infant car restraint test guidelines, see Family-Centered Care box, p. 341.)
Another automobile-related hazard for infants is overheating (hyperthermia) and subsequent death when left in a vehicle in hot weather (>26.4° C [80° F]). Infants dissipate heat poorly, and an increase in body temperature may cause death in a few hours. Caution parents against leaving infants in a vehicle alone for any reason. A small sign or placard has been designed to hang in the rear-view mirror to remind the parent that there is a child in the back seat. Busy parents may forget the child in the back when preoccupied with errands, children’s school and extracurricular activities, and busy work schedules.
Residential injuries, especially falls, accounted for the highest incidence of unintentional injuries to children seen in emergency departments in the United States (Phelan, Khoury, Kalkwarf, et al, 2005). A study of childhood injuries found that beginning at the age of 3 to 5 months, the incidence of falls increased dramatically with increasing age, peaking at 15 to 17 months of age. Most falls were from heights such as furniture, stairs, and buildings (Agran, Anderson, Winn, et al, 2003). A large percentage of infants have fallen as a result of being dropped or falling out of car seats, down stairs, or from child walkers (Pickett, Streight, Simpson, et al, 2003; Dedoukou, Spyridopoulos, Kedikoglou, et al, 2004). Falls from shopping carts and bunk beds also contribute to a significant number of injuries in small children (Wright, Griffin, MacLennan, et al, 2008; D’Souza, Smith, and McKenzie, 2008).
Infant walkers are responsible for a number of different types of injuries that occur when the walker tips over or falls down stairs. Warn parents of these dangers and encourage them to keep constant watch on their child’s activities; discourage the use of walkers. The American Academy of Pediatrics (2001) does not recommend the use of walkers with wheels. One alternative is to use a stationary play station with a seat similar to that of a walker. There is no evidence that infant walkers help infants walk sooner.
Once infants are mobile, they should not be allowed to crawl unsupervised on any raised surface, near stairs, or near any water reservoir. Gates should be used at the bottom and top of stairs, since both present dangers to the crawling and climbing infant. As children begin to pull themselves to a standing position, heavy objects, such as unsturdy furniture, televisions, compact disc players, or any freestanding item (e.g., wrought iron fish tank stands or concrete birdbath), can be extremely dangerous if pulled down on top of the child. To prevent injury from furniture tipping over, place televisions on lower furniture and as far back as possible. Angle braces or anchors can secure furniture to walls.
Poisoning is one of the major causes of death in children younger than 5 years of age. The highest incidence occurs in the 2-year-old group, with the second highest incidence occurring in 1-year-old children. Infants who do not crawl are relatively free from the danger of poisonous agents because they are immobile. However, once they become mobile, danger from poisoning is almost everywhere. The average home contains more than 500 toxic substances, and approximately one third of all poisonings occur in the kitchen.
The major reason for ingestion of poisons is improper storage. To protect the infant, toxic agents should not be placed on a low shelf, table, or floor. Plants are another source of poisoning for infants. Plants are commonly placed on the floor, and the leaves or flowers are attractive and easy to pull off. More than 700 species of plants are known to cause illness or death. Common household over-the-counter medications such as acetaminophen and cold and cough preparations, cosmetics and personal care products, and cleaning products are also sources of childhood poisoning (Wilkerson, Northington, and Fisher, 2005).
Another danger is ingestion of the button-sized batteries used in devices such as hearing aids, calculators, watches, and cameras. Because they are bright and shiny, they are attractive to children. However, they can cause severe morbidity, even death, if lodged in the esophagus. The strong alkali in a battery can leak and cause a severe caustic burn. As a precaution, small batteries must be safely stored and discarded where young children cannot easily retrieve them.
Not all poisonings result from ingestion; another possible route is inhalation, such as inhaling chlorine vapors from household cleaning or pool supplies. Passive cocaine toxicity has occurred in young children exposed to freebase cocaine (“crack”) smoking by adults. The production of methamphetamines, a common central nervous system stimulant also known as ice, speed, or crystal, involves a number of chemicals that may be toxic alone (contact or ingestion) or during the production (cooking) of the drug itself. Methamphetamine laboratories are commonly in household areas where children may be exposed to harmful inhalants and to open fires where meth is “cooked.” Methamphetamine laboratories are also often mobile, and children may be similarly exposed to dangerous chemicals (Farst, Duncan, Moss, et al, 2007). Methamphetamine use and exposure have been shown to cause developmental problems and short- and long-term brain damage, particularly in children. Reports of the number of children exposed daily to methamphetamine laboratories in the United States and Canada are alarming. Such children are also at high risk for abuse and neglect because their caretakers are preoccupied with production, sale, and use of the drug (Bellemare, 2008; Matteucci, Auten, Crowley, et al, 2007; Mecham and Melini, 2002). Children should be protected from environments in which inhaled toxins exist. (See Chapter 32 for discussion of effects of chemical substances on the fetus and neonate.)
The only certain way to prevent poisoning is to remove toxic agents, which means placing containers out of the infant’s reach or contact. Because crawling infants soon become climbing toddlers, it is best to keep all toxic agents, especially drugs, in a locked cabinet. Special plastic hooks can be attached to the inside of cabinet doors to keep them securely closed. Firm thumb pressure is required to unlatch the hook, and small children are usually unable to manipulate them. Locks are best, but for frequently used cleaning agents, such as those often kept under a kitchen sink, hooks are a practical alternative.
With several hundred toxic substances in each house, locking them all up can present a problem. Potentially hazardous substances should not be stored in any type of food container. A popular container used to store toxic liquids is a soda or pop bottle. A child who is unaware of the dangerous contents is vulnerable to poisoning. Parents should know the telephone number of local poison control centers and call in the event of a suspected poisoning. Chapter 16 discusses emergency measures for poisoning.
Scalding from water that is too hot; excessive sunburn; and burns from house fires, electrical wires, sockets, and heating elements such as radiators, registers, and floor furnaces cause a significant number of deaths and many more injuries in infants. The infant’s skin is particularly sensitive to irritation, and the mechanisms for temperature perception are not completely developed. As a general precaution, all homes should have smoke alarms installed near the bedroom areas and on each level of the building.
Scald burns from hot tap water can be prevented by lowering the hot water heater to a safe temperature of 49° C (120° F). In addition, parents should check the bath water before placing the infant in it. The two most common types of scald injury are from the child pulling a hot pan of water off a stove or elevated surface or overturning a container of hot water on herself or himself (Drago, 2005). The handles of cooking utensils should be turned toward the back of the stove. When the infant is underfoot, caretakers should avoid pouring hot liquids and cooking with hot oil. Hanging tablecloths should also be out of the infant’s reach to prevent pulling hot items off the table.
Scalds can also occur from bathing infants in the kitchen sink when the garbage disposal, occluded with debris, causes the draining dishwasher effluent to back up into the sink. The temperature of the effluent from a dishwasher is typically that of the maximum water temperature of the household water heater, but many dishwashers are equipped with heating elements that heat water to an even higher temperature. As a precaution, instruct caregivers to avoid bathing small children in the kitchen sink while the dishwasher is running.
If formula or food is warmed in a microwave oven, parents must check it before feeding because the container may remain cool while the contents are hot. Oropharyngeal burns from the contents of baby bottles heated in a microwave have been reported. Another danger is explosion of the bottle from the buildup of steam. Because of these dangers, parents should avoid microwaving infant formula or food or do it using the guidelines in the Family-Centered Care box on p. 490.
Sunburn can be a source of a first- or second-degree burn. Exposure to direct sunlight should be avoided for the first 6 months. When infants are in the sun, the body, especially the face and head, should be covered. Sunscreen can be used on older infants but should be used on small areas of the body and sparingly in infants under 6 months. (See Sunburn, Chapter 18.) Although dark-skinned infants burn less readily, their thin skin can become sunburned and needs protection.
Electrical outlets should be covered with protective plastic caps that prevent the child from sucking on the outlet or putting metal objects into it. Live wires are placed out of reach so that curious infants cannot chew on them and break the rubber coating. Infants should not be allowed to play near television sets, stereo units, or other appliances, whether these units are turned on or off, because infants cannot determine when the appliance is safe.
Any heat-producing element should have a guard in front of it. Fireplaces should be well screened because they are appealing and within easy access. Small portable heaters should be placed on a high surface. Floor furnaces should have barrier gates to prevent children from crawling or walking over them. Burning cigarettes, candles, and incense should be kept out of reach, and infants should not be held by a smoking adult because falling ashes are a hazard, especially to the eyes. Heated-mist vaporizers are a source of burns and should not be used. If humidity is needed, only cool mist vaporizers are safe.
By law, all infant sleepwear must be flame retardant. Unfortunately, this does not apply to all infant clothing. Flame-retardant fabric is not the ultimate protection against burns. Repeated washing reduces the flame-retardant properties, and the use of soap or bleach destroys the protection. If sleepwear is home sewn, advise parents to look for specially treated, flame-retardant fabric.
Another type of thermal injury occurs when children are exposed to excessive heat during confinement in poorly ventilated vehicles. The practice of leaving the windows open a couple of inches is not protective. The nurse should caution parents never to leave children in parked cars, especially when the automobile is in direct sunlight.
Children can also be burned by overheated metal hardware and vinyl seats in cars parked in the sun. As a precaution, the surface heat of car restraints should be determined before placing children in them. Covering the restraints and hardware (such as metal latches on seat belts) may be necessary to prevent skin burns. An additional safeguard is buying a light-colored restraint, which absorbs less heat.
Drowning in this age-group can occur in just an inch or 2 of water. Consequently, infants should always be supervised in a bathtub and near a source of water such as a swimming pool, lake, toilet, or bucket. A survey found that most drownings among infants younger than age 1 year took place in a toilet, bathtub, or bucket (Lassman, 2002). Five-gallon buckets are particularly dangerous because the child may inadvertently fall in head first and, because of the weight of the upper body at this age, may be unable to withdraw from the bucket. Somers, Chiasson, and Smith (2006) noted that 72% of pediatric bathtub drownings occurred in infants under 12 months of age, and inadequate adult supervision was the leading associated factor (89% of cases). Organized swimming instruction is not recommended for children younger than 4 years of age, since it may lead to a false sense of security (American Academy of Pediatrics, 2003). Infants cannot learn the elements of water safety or react appropriately in an emergency. Therefore all young children need to be considered at risk when near water. Infants and toddlers are also at increased risk of infection and seizures from swallowing large amounts of water.
Injuries can occur in numerous ways. Sharp, jagged-edged objects can cause wounds in the skin. Long-pointed items, such as a toothpick or fork, can be poked into the eye or ear, causing serious damage. Such articles should be safely stored away from the infant’s reach. Forks are best avoided for self-feeding until the child has mastered the spoon, usually by age 18 months.
In addition to hazards such as aspiration, infants can place small articles in the ear or nose, and excessive noise from toys can result in sensorineural hearing loss. Although toys with the highest noise levels are model airplanes, air guns, and toy cap guns, even common squeaking toys used by young children may be harmful if placed close to the ear.
A Centers for Disease Control and Prevention report (2008a) highlights the fact that in 2005 to 2006, 19% of child maltreatment fatalities in the United States occurred in infants less than 1 year of age. Homicide statistics suggest the fatality risk is highest in the infant’s first week of life. Nonfatal maltreatment data for the same period indicate that 38.8% of infants maltreated were less than 1 month of age; 84% of those were less than 1 week old. Neglect and physical abuse were the most frequently reported forms of maltreatment. A high rate of battering injury has been reported in infants 0 to 5 months (Agran, Anderson, Winn, et al, 2003).
Another commonly unrecognized danger to infants is animal attacks. As newcomers to the home, helpless infants can provoke jealousy in animals, especially dogs and cats. Parents must be aware and protect the child from household pets and farm animals. (See Mammal Bites, Chapter 18.)
The task of injury prevention begins to be appreciated only when the potential environmental dangers to which infants are vulnerable are considered. Injury prevention and parent education should be handled on a growth and developmental basis. It is simply impossible to completely protect infants and small children from all potential dangers without placing them in a sterile, impractical environment. However, a large percentage of childhood deaths continue to occur as a result of preventable injuries (Martin, Kochanek, Strobino, et al, 2005). Nurses must be aware of the possible causes of injury in each age-group to provide anticipatory, preventive teaching. For example, the nurse should discuss guidelines for injury prevention during infancy (see Box 12-6) before the child reaches the susceptible age-group. Preventive teaching ideally begins during pregnancy.
Two thirds of all injuries to children occur in the home, and therefore safety is essential to emphasize with parents. The nurse can give parents a home safety checklist to increase their awareness of danger areas in the home and assist them in implementing safety devices and practices before an injury occurs (see Family-Centered Care box). Hands-on displays such as cabinet latches or toilet seat locks can familiarize parents with inexpensive, commercial devices that can be used in the home to prevent injuries.
To help parents appreciate the dangers present in their home to young children, suggest that they get eye level with the floor to survey the environment from a curious child’s view.
Injury prevention requires protection of the child and education of the caregiver. Nurses in ambulatory care settings; health maintenance centers; and home health, public health, or visiting nurse agencies are in a most favorable position for injury education. This does not exclude nurses in inpatient facilities, who could use visiting times for discussing this topic. Although early postpartum discharge may be restrictive, this is an excellent opportunity to introduce the family to infant safety and safety for other children in the household as well. Pamphlets, safety checklists, and brief information sessions describing potential dangers and remedies aimed at preventing injury can help the new family get off to a good beginning with the new infant.
One approach to teaching injury prevention is to relate why children in various age-groups are prone to specific types of injuries. Stressing prevention is just as important as emphasizing why the injury occurs. However, injury prevention must also be practical. Asking parents for their ideas leads to realistic suggestions they can follow.
Parents need to remember that infants and young children cannot anticipate danger or understand when it is or is not present. Although parents can always explain to the child why something is dangerous, they also must remember that small children need to be physically removed from the situation. It is not easy to teach safety, supervise closely, and refrain from saying “no” a hundred times a day. Parents become acutely aware of this dilemma as soon as the infant learns to crawl and pull up to furniture. Preventing injuries is usually the first reason for limit setting and discipline, but limits are also set to prevent damage to valuable household objects. When small children are in the home, parents must remove or guard dangerous objects and place valuable articles out of reach.
When children learn the meaning of “no,” they should also learn what “yes” means. Parents should praise children for playing with suitable toys, reinforce their efforts at behaving or listening, and provide innovative and creative recreational toys for them. Infants love to tear paper and avidly pursue books, magazines, or newspapers left on the floor. Instead of always scolding them for destroying a valued book, keep child-safe books (such as those constructed of fabric) available for them to play with. If they enjoy pots and pans, a cabinet can be arranged with safe utensils for them to explore.
One additional factor must be stressed concerning injury prevention and education. Children are imitators; they copy what they see and hear. Thus practicing safety teaches safety, a rule that applies to parents and their children and to nurses and their clients. Saying one thing but doing another confuses children and can lead to difficulties as the child grows older.
Childrearing is no easy task; it presents challenges to both new and seasoned parents. With society’s changing roles and mores, combined with a highly mobile population, traditional role models and time-honored methods of raising children are declining. As a result, parents look to professionals for guidance. Nurses are in an advantageous position to render assistance and offer suggestions. Every phase of a child’s life has its particular traumas—toilet training for toddlers, unexplained fears for preschoolers, and identity crises for adolescents. For parents of an infant some challenges center around dependency, discipline, increased mobility, and safety. Major areas for parental guidance during the first year are listed in the Family-Centered Care box.
• The child’s biologic development encompasses proportional changes; sensory changes, including binocularity, depth perception, and visual preference; maturation of biologic systems; fine motor development; and gross motor development.
• Erikson’s theory of psychosocial development states that, from birth to 1 year, the infant is concerned with acquiring a sense of trust while overcoming a sense of mistrust.
• Piaget’s theory of cognitive development, as it applies to the infant, focuses on the sensorimotor phase, which includes the use of reflexes, primary circular reactions, secondary circular reactions, and coordination of secondary schemas and their application to new situations.
• Development of body image begins in infancy; by 1 year of age infants recognize that they are distinct from their parents.
• Social development of the infant is guided by attachment, language development, personal-social behavior, and participation in play.
• Temperament influences the type of interaction that occurs between the child, parents, and siblings.
• Parents face many concerns, including infant fears, daycare, limit setting and discipline, thumb sucking and pacifier use, teething, and choice of infant shoes.
• Breast milk is the most desirable food for the infant for the first 6 to 12 months. Commercial iron-fortified formula is an acceptable choice for infant nutrition when breast-feeding is not an option, followed by gradual introduction of solid food during the second 6 months. Whole milk is not recommended until after 12 months.
• Common sleep problems that develop during infancy—and that are easily prevented—are associated with night crying and feeding. Nurses should instruct the parents, after careful assessment, in strategies to deal with the specific problem.
• Cleaning the gums and teeth regularly and appropriate dietary intake promote good dental health.
• Recommended routine immunizations include those for hepatitis B, hepatitis A, diphtheria, tetanus, pertussis, polio, measles, mumps, rubella, pneumococcal, chickenpox, meningococcal, influenza, and H. influenzae type b.
• Combination vaccines are effective and decrease the total amount of injections a child must receive.
• Because injuries are a major cause of death during infancy, parents should be alerted to dangers of aspiration of foreign objects, suffocation, falls, poisoning, burns, motor vehicle injuries, and bodily damage, as well as preventive actions needed to make the environment safe for infants.
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*Recommended resources for parents are Turecki SK, Tonner L: The difficult child, 2000, Bantam Books, New York, NY (www.randomhouse.com); and Chess S, Thomas A: Know your child: an authoritative guide for today’s parents, Lanham, Md, 1996, Jason Aronson (www.aronson.com).
*Information about accreditation criteria and procedures of the National Academy for Early Childhood Program Accreditation/NAEYC is available from the National Association for the Education of Young Children, 1313 L St. NW, Suite 500, Washington, DC 20005; 800-424-2460 or 202-232-8777; www.naeyc.org. These criteria are excellent guidelines for evaluating child care facilities. Other resources are (1) Child Care: What’s Best for Your Family and a number of other child care articles and pamphlets from American Academy of Pediatrics, 141 Northwest Point Blvd., Elk Grove Village, IL 60007; 847-434-4000; http://aap.org; and (2) Child Care Aware, 800-424-2246; www.childcareaware.org.
*See also The CDC Guide to Breastfeeding Interventions (Shealy, Benton-Davis, and Grummer-Strawn, 2005), which includes information for working and breast-feeding.
*An excellent resource for parents is Ferber R: Solve your child’s sleep problems, New York, 2006, Simon & Schuster (800-223-2336; www.simonandschuster.com). Also available in Spanish.
*Because of constant changes in the pharmaceutical industry, trade names of single and combination vaccines in this section may differ from those currently available. The reader is encouraged to access the vaccine page of the Center for Biologics Evaluation and Research (CBER) of the Food and Drug Administration for the latest licensed vaccine trade names: www.fda.gov/BiologicsBloodVaccines/Vaccines/default.htm.
*A number of parent education pamphlets—such as Crib Safety Tips and Is Your Used Crib Safe?—are available in English and Spanish from the U.S. Consumer Product Safety Commission, Publication Request, Washington, DC 20207; 800-638-2772; www.cpsc.gov.
*An air bag safety fact sheet is available from the American Academy of Pediatrics, 141 Northwest Point Blvd., Elk Grove Village, IL 60007; www.aap.org. Car seat information is available at www.aap.org/family/carseatguide.htm; and from the Insurance Institute for Highway Safety, 1005 N. Glebe Road, Suite 800, Arlington, VA 22201; 703-247-1500; fax: 703-247-1588; www.iihs.org. The National Highway Traffic Safety Administration, www.nhtsa.gov, also provides child passenger safety and air bag safety information for parents.