Table of Contents
Part I: The Field of Pediatrics
Chapter 1: Overview of Pediatrics
Chapter 2: Quality and Safety in Health Care for Children
Chapter 3: Ethics in Pediatric Care
Chapter 4: Cultural Issues in Pediatric Care
Chapter 5: Maximizing Children’s Health
Part II: Growth, Development, and Behavior
Chapter 6: Overview and Assessment of Variability
Chapter 10: The Preschool Years
Chapter 13: Assessment of Growth
Chapter 14: Developmental-Behavioral Screening and Surveillance
Chapter 16: Loss, Separation, and Bereavement
Part III: Behavioral and Psychiatric Disorders
Chapter 18: Assessment and Interviewing
Chapter 19: Psychologic Treatment of Children and Adolescents
Chapter 20: Psychosomatic Illness
Chapter 21: Rumination, Pica, and Elimination (Enuresis, Encopresis) Disorders
Chapter 22: Habit and Tic Disorders
Chapter 25: Suicide and Attempted Suicide
Chapter 27: Disruptive Behavioral Disorders
Chapter 28: Pervasive Developmental Disorders and Childhood Psychosis
Chapter 29: Neurodevelopmental Function and Dysfunction in the School-Aged Child
Chapter 30: Attention-Deficit/Hyperactivity Disorder
Chapter 32: Language Development and Communication Disorders
Chapter 33: Intellectual Disability
Part V: Children with Special Needs
Chapter 35: Foster and Kinship Care
Chapter 36: Impact of Violence on Children
Chapter 37: Abused and Neglected Children
Chapter 39: Chronic Illness in Childhood
Chapter 40: Pediatric Palliative Care
Chapter 41: Nutritional Requirements
Chapter 42: Feeding Healthy Infants, Children, and Adolescents
Chapter 43: Nutrition, Food Security, and Health
Chapter 44: Overweight and Obesity
Chapter 45: Vitamin A Deficiencies and Excess
Chapter 46: Vitamin B Complex Deficiency and Excess
Chapter 47: Vitamin C (Ascorbic Acid)
Chapter 48: Rickets and Hypervitaminosis D
Chapter 49: Vitamin E Deficiency
Chapter 50: Vitamin K Deficiency
Chapter 51: Micronutrient Mineral Deficiencies
Part VII: Pathophysiology of Body Fluids and Fluid Therapy
Chapter 52: Electrolyte and Acid-Base Disorders
Chapter 53: Maintenance and Replacement Therapy
Chapter 55: Fluid and Electrolyte Treatment of Specific Disorders
Part VIII: Pediatric Drug Therapy
Chapter 56: Pediatric Pharmacogenetics, Pharmacogenomics, and Pharmacoproteomics
Chapter 57: Principles of Drug Therapy
Chapter 59: Herbs, Complementary Therapies, and Integrative Medicine
Part IX: The Acutely Ill Child
Chapter 60: Evaluation of the Sick Child in the Office and Clinic
Chapter 61: Emergency Medical Services for Children
Chapter 62: Pediatric Emergencies and Resuscitation
Chapter 63: Neurologic Emergencies and Stabilization
Chapter 65: Respiratory Distress and Failure
Chapter 66: Acute Care of the Victim of Multiple Trauma
Chapter 67: Drowning and Submersion Injury
Chapter 70: Anesthesia, Perioperative Care, and Sedation
Chapter 71: Pediatric Pain Management
Chapter 72: Integration of Genetics into Pediatric Practice
Chapter 73: The Genetic Approach in Pediatric Medicine
Chapter 75: Patterns of Genetic Transmission
Chapter 77: Genetics of Common Disorders
Part XI: Genetic Disorders of Metabolism
Chapter 78: An Approach to Inborn Errors of Metabolism
Chapter 79: Defects in Metabolism of Amino Acids
Chapter 80: Defects in Metabolism of Lipids
Chapter 81: Defects in Metabolism of Carbohydrates
Chapter 82: Mucopolysaccharidoses
Chapter 83: Disorders of Purine and Pyrimidine Metabolism
Part XII: The Fetus and the Neonatal Infant
Chapter 87: Overview of Mortality and Morbidity
Chapter 88: The Newborn Infant (See Also Chapter 7)
Chapter 89: High-Risk Pregnancies
Chapter 91: The High-Risk Infant
Chapter 92: Clinical Manifestations of Diseases in the Newborn Period
Chapter 93: Nervous System Disorders
Chapter 94: Delivery Room Emergencies
Chapter 95: Respiratory Tract Disorders
Chapter 96: Digestive System Disorders
Chapter 98: Genitourinary System (See Also Part XXIV)
Chapter 100: Metabolic Disturbances
Chapter 101: The Endocrine System
Chapter 103: Infections of the Neonatal Infant
Part XIII: Adolescent Medicine
Chapter 104: Adolescent Development
Chapter 105: The Epidemiology of Adolescent Health Problems
Chapter 106: Delivery of Health Care to Adolescents
Chapter 110: Menstrual Problems
Chapter 112: Adolescent Pregnancy
Chapter 114: Sexually Transmitted Infections
Chapter 115: Chronic Fatigue Syndrome
Section 1: Evaluation of the Immune System
Chapter 116: Evaluation of Suspected Immunodeficiency
Section 2: The T-, B-, and NK-Cell Systems
Chapter 117: T Lymphocytes, B Lymphocytes, and Natural Killer Cells
Chapter 118: Primary Defects of Antibody Production
Chapter 119: Primary Defects of Cellular Immunity
Chapter 120: Primary Combined Antibody and Cellular Immunodeficiencies
Section 3: The Phagocytic System
Chapter 122: Monocytes, Macrophages, and Dendritic Cells
Chapter 124: Disorders of Phagocyte Function
Section 4: The Complement System
Chapter 127: The Complement System
Chapter 128: Disorders of the Complement System
Section 5: Hematopoietic Stem Cell Transplantation
Chapter 129: Principles and Clinical Indications
Chapter 130: HSCT from Alternative Sources and Donors
Chapter 131: Graft Versus Host Disease (GVHD) and Rejection
Chapter 132: Infectious Complications of HSCT
Chapter 133: Late Effects of HSCT
Chapter 134: Allergy and the Immunologic Basis of Atopic Disease
Chapter 135: Diagnosis of Allergic Disease
Chapter 136: Principles of Treatment of Allergic Disease
Chapter 137: Allergic Rhinitis
Chapter 139: Atopic Dermatitis (Atopic Eczema)
Chapter 142: Urticaria (Hives) and Angioedema
Chapter 145: Adverse Reactions to Foods
Chapter 146: Adverse Reactions to Drugs
Part XVI: Rheumatic Diseases of Childhood
Chapter 147: Evaluation of Suspected Rheumatic Disease
Chapter 148: Treatment of Rheumatic Diseases
Chapter 149: Juvenile Idiopathic Arthritis
Chapter 150: Ankylosing Spondylitis and Other Spondyloarthritides
Chapter 151: Reactive and Postinfectious Arthritis
Chapter 152: Systemic Lupus Erythematosus
Chapter 153: Juvenile Dermatomyositis
Chapter 154: Scleroderma and Raynaud Phenomenon
Chapter 157: Hereditary Periodic Fever Syndromes
Chapter 161: Vasculitis Syndromes
Chapter 162: Musculoskeletal Pain Syndromes
Chapter 163: Miscellaneous Conditions Associated with Arthritis
Part XVII: Infectious Diseases
Section 1: General Considerations
Chapter 164: Diagnostic Microbiology
Section 2: Preventive Measures
Chapter 165: Immunization Practices
Chapter 166: Infection Prevention and Control
Chapter 167: Child Care and Communicable Diseases
Chapter 168: Health Advice for Children Traveling Internationally
Chapter 170: Fever without a Focus
Chapter 171: Infections in Immunocompromised Persons
Chapter 172: Infection Associated with Medical Devices
Chapter 173: Principles of Antibacterial Therapy
Section 4: Gram-Positive Bacterial Infections
Chapter 175: Streptococcus pneumoniae (Pneumococcus)
Chapter 176: Group A Streptococcus
Chapter 177: Group B Streptococcus
Chapter 178: Non–Group A or B Streptococci
Chapter 180: Diphtheria (Corynebacterium diphtheriae)
Chapter 181: Listeria monocytogenes
Section 5: Gram-Negative Bacterial Infections
Chapter 184: Neisseria meningitidis (Meningococcus)
Chapter 185: Neisseria gonorrhoeae (Gonococcus)
Chapter 186: Haemophilus influenzae
Chapter 187: Chancroid (Haemophilus ducreyi)
Chapter 188: Moraxella catarrhalis
Chapter 189: Pertussis (Bordetella pertussis and Bordetella parapertussis)
Chapter 196: Aeromonas and Plesiomonas
Chapter 197: Pseudomonas, Burkholderia, and Stenotrophomonas
Chapter 198: Tularemia (Francisella tularensis)
Section 6: Anaerobic Bacterial Infections
Chapter 202: Botulism (Clostridium botulinum)
Chapter 203: Tetanus (Clostridium tetani)
Chapter 204: Clostridium difficile Infection
Chapter 205: Other Anaerobic Infections
Section 7: Mycobacterial Infections
Chapter 206: Principles of Antimycobacterial Therapy
Chapter 207: Tuberculosis (Mycobacterium tuberculosis)
Chapter 208: Hansen Disease (Mycobacterium leprae)
Chapter 209: Nontuberculous Mycobacteria
Section 8: Spirochetal Infections
Chapter 210: Syphilis (Treponema pallidum)
Chapter 211: Nonvenereal Treponemal Infections
Chapter 213: Relapsing Fever (Borrelia)
Chapter 214: Lyme Disease (Borrelia burgdorferi)
Section 9: Mycoplasmal Infections
Chapter 215: Mycoplasma pneumoniae
Section 10: Chlamydial Infections
Chapter 217: Chlamydophila pneumoniae
Chapter 218: Chlamydia trachomatis
Chapter 219: Psittacosis (Chlamydophila psittaci)
Section 11: Rickettsial Infections
Chapter 220: Spotted Fever and Transitional Group Rickettsioses
Chapter 221: Scrub Typhus (Orientia tsutsugamushi)
Chapter 222: Typhus Group Rickettsioses
Chapter 223: Ehrlichioses and Anaplasmosis
Chapter 224: Q Fever (Coxiella burnetii)
Chapter 225: Principles of Antifungal Therapy
Chapter 227: Cryptococcus neoformans
Chapter 230: Histoplasmosis (Histoplasma capsulatum)
Chapter 231: Blastomycosis (Blastomyces dermatitidis)
Chapter 232: Coccidioidomycosis (Coccidioides Species)
Chapter 233: Paracoccidioides brasiliensis
Chapter 234: Sporotrichosis (Sporothrix schenckii)
Chapter 235: Zygomycosis (Mucormycosis)
Chapter 236: Pneumocystis jirovecii
Chapter 237: Principles of Antiviral Therapy
Chapter 242: Nonpolio Enteroviruses
Chapter 244: Herpes Simplex Virus
Chapter 245: Varicella-Zoster Virus Infections
Chapter 246: Epstein-Barr Virus
Chapter 248: Roseola (Human Herpes Viruses 6 and 7)
Chapter 249: Human Herpesvirus 8
Chapter 250: Influenza Viruses
Chapter 251: Parainfluenza Viruses
Chapter 252: Respiratory Syncytial Virus
Chapter 253: Human Metapneumovirus
Chapter 257: Rotaviruses, Caliciviruses, and Astroviruses
Chapter 258: Human Papillomaviruses
Chapter 259: Arboviral Encephalitis in North America
Chapter 260: Arboviral Encephalitis outside North America
Chapter 261: Dengue Fever and Dengue Hemorrhagic Fever
Chapter 263: Other Viral Hemorrhagic Fevers
Chapter 264: Lymphocytic Choriomeningitis Virus
Chapter 265: Hantavirus Pulmonary Syndrome
Chapter 268: Acquired Immunodeficiency Syndrome (Human Immunodeficiency Virus)
Chapter 269: Human T-Lymphotropic Viruses (1 and 2)
Chapter 270: Transmissible Spongiform Encephalopathies
Section 14: Antiparasitic Therapy
Chapter 271: Principles of Antiparasitic Therapy
Section 15: Protozoan Diseases
Chapter 272: Primary Amebic Meningoencephalitis
Chapter 274: Giardiasis and Balantidiasis
Chapter 275: Cryptosporidium, Isospora, Cyclospora, and Microsporidia
Chapter 276: Trichomoniasis (Trichomonas vaginalis)
Chapter 277: Leishmaniasis (Leishmania)
Chapter 278: African Trypanosomiasis (Sleeping Sickness; Trypanosoma brucei Complex)
Chapter 279: American Trypanosomiasis (Chagas Disease; Trypanosoma cruzi)
Chapter 280: Malaria (Plasmodium)
Chapter 281: Babesiosis (Babesia)
Chapter 282: Toxoplasmosis (Toxoplasma gondii)
Section 16: Helminthic Diseases
Chapter 283: Ascariasis (Ascaris lumbricoides)
Chapter 284: Hookworms (Necator americanus and Ancylostoma spp.)
Chapter 285: Trichuriasis (Trichuris trichiura)
Chapter 286: Enterobiasis (Enterobius vermicularis)
Chapter 287: Strongyloidiasis (Strongyloides stercoralis)
Chapter 288: Lymphatic Filariasis (Brugia malayi, Brugia timori, and Wuchereria bancrofti)
Chapter 289: Other Tissue Nematodes
Chapter 290: Toxocariasis (Visceral and Ocular Larva Migrans)
Chapter 291: Trichinosis (Trichinella spiralis)
Chapter 292: Schistosomiasis (Schistosoma)
Chapter 293: Flukes (Liver, Lung, and Intestinal)
Chapter 294: Adult Tapeworm Infections
Chapter 296: Echinococcosis (Echinococcus granulosus and Echinococcus multilocularis)
Part XVIII: The Digestive System
Section 1: Clinical Manifestations of Gastrointestinal Disease
Chapter 297: Normal Digestive Tract Phenomena
Chapter 298: Major Symptoms and Signs of Digestive Tract Disorders
Chapter 299: Development and Developmental Anomalies of the Teeth
Chapter 300: Disorders of the Oral Cavity Associated with Other Conditions
Chapter 302: Cleft Lip and Palate
Chapter 303: Syndromes with Oral Manifestations
Chapter 305: Periodontal Diseases
Chapter 307: Common Lesions of the Oral Soft Tissues
Chapter 308: Diseases of the Salivary Glands and Jaws
Chapter 309: Diagnostic Radiology in Dental Assessment
Chapter 310: Embryology, Anatomy, and Function of the Esophagus
Chapter 311: Congenital Anomalies
Chapter 312: Obstructing and Motility Disorders of the Esophagus
Chapter 315: Gastroesophageal Reflux Disease
Chapter 316: Eosinophilic Esophagitis and Non-GERD Esophagitis
Chapter 317: Esophageal Perforation
Chapter 318: Esophageal Varices
Section 4: Stomach and Intestines
Chapter 320: Normal Development, Structure, and Function
Chapter 321: Pyloric Stenosis and Other Congenital Anomalies of the Stomach
Chapter 322: Intestinal Atresia, Stenosis, and Malrotation
Chapter 324: Motility Disorders and Hirschsprung Disease
Chapter 325: Ileus, Adhesions, Intussusception, and Closed-Loop Obstructions
Chapter 326: Foreign Bodies and Bezoars
Chapter 327: Peptic Ulcer Disease in Children
Chapter 328: Inflammatory Bowel Disease
Chapter 329: Eosinophilic Gastroenteritis
Chapter 330: Disorders of Malabsorption
Chapter 331: Intestinal Transplantation in Children with Intestinal Failure
Chapter 332: Acute Gastroenteritis in Children
Chapter 334: Functional Abdominal Pain (Nonorganic Chronic Abdominal Pain)
Chapter 335: Acute Appendicitis
Chapter 336: Surgical Conditions of the Anus and Rectum
Chapter 337: Tumors of the Digestive Tract
Chapter 339: Embryology, Anatomy, and Physiology
Chapter 340: Pancreatic Function Tests
Chapter 341: Disorders of the Exocrine Pancreas
Chapter 342: Treatment of Pancreatic Insufficiency
Chapter 344: Pseudocyst of the Pancreas
Chapter 345: Pancreatic Tumors
Section 6: The Liver and Biliary System
Chapter 346: Morphogenesis of the Liver and Biliary System
Chapter 347: Manifestations of Liver Disease
Chapter 349: Metabolic Diseases of the Liver
Chapter 352: Liver Disease Associated with Systemic Disorders
Chapter 353: Mitochondrial Hepatopathies
Chapter 354: Autoimmune Hepatitis
Chapter 355: Drug- and Toxin-Induced Liver Injury
Chapter 356: Fulminant Hepatic Failure
Chapter 357: Cystic Diseases of the Biliary Tract and Liver
Chapter 358: Diseases of the Gallbladder
Chapter 359: Portal Hypertension and Varices
Chapter 360: Liver Transplantation
Chapter 364: Epigastric Hernia
Section 1: Development and Function
Chapter 365: Respiratory Pathophysiology and Regulation
Chapter 366: Diagnostic Approach to Respiratory Disease
Chapter 367: Sudden Infant Death Syndrome
Section 2: Disorders of the Respiratory Tract
Chapter 368: Congenital Disorders of the Nose
Chapter 369: Acquired Disorders of the Nose
Chapter 373: Acute Pharyngitis
Chapter 375: Tonsils and Adenoids
Chapter 376: Chronic or Recurrent Respiratory Symptoms
Chapter 378: Congenital Anomalies of the Larynx, Trachea, and Bronchi
Chapter 379: Foreign Bodies of the Airway
Chapter 380: Laryngotracheal Stenosis and Subglottic Stenosis
Chapter 381: Bronchomalacia and Tracheomalacia
Chapter 382: Neoplasms of the Larynx, Trachea, and Bronchi
Chapter 383: Wheezing, Bronchiolitis, andBronchitis
Chapter 384: Emphysema and Overinflation
Chapter 385: α1-Antitrypsin Deficiency and Emphysema
Chapter 386: Other Distal Airway Diseases
Chapter 387: Congenital Disorders of the Lung
Chapter 389: Aspiration Syndromes
Chapter 390: Chronic Recurrent Aspiration
Chapter 392: Community-Acquired Pneumonia
Chapter 394: Pulmonary Abscess
Chapter 396: Primary Ciliary Dyskinesia (Immotile Cilia Syndrome)
Chapter 397: Interstitial Lung Diseases
Chapter 398: Pulmonary Alveolar Proteinosis
Chapter 399: Inherited Disorders of Surfactant Metabolism
Chapter 400: Pulmonary Hemosiderosis
Chapter 401: Pulmonary Embolism, Infarction, and Hemorrhage
Chapter 404: Pleurisy, Pleural Effusions, and Empyema
Chapter 406: Pneumomediastinum
Chapter 410: Bronchopulmonary Dysplasia
Chapter 411: Skeletal Diseases Influencing Pulmonary Function
Chapter 412: Chronic Severe Respiratory Insufficiency
Chapter 413: Extrapulmonary Diseases with Pulmonary Manifestations
Part XX: The Cardiovascular System
Section 1: Developmental Biology of the Cardiovascular System
Chapter 414: Cardiac Development
Chapter 415: The Fetal to Neonatal Circulatory Transition
Section 2: Evaluation of the Cardiovascular System
Chapter 416: History and Physical Examination
Chapter 417: Laboratory Evaluation
Section 3: Congenital Heart Disease
Chapter 418: Epidemiology and Genetic Basis of Congenital Heart Disease
Chapter 419: Evaluation of the Infant or Child with Congenital Heart Disease
Chapter 420: Acyanotic Congenital Heart Disease
Chapter 421: Acyanotic Congenital Heart Disease
Chapter 422: Acyanotic Congenital Heart Disease
Chapter 423: Cyanotic Congenital Heart Disease
Chapter 424: Cyanotic Congenital Heart Lesions
Chapter 425: Cyanotic Congenital Heart Disease
Chapter 426: Other Congenital Heart and Vascular Malformations
Chapter 427: Pulmonary Hypertension
Chapter 428: General Principles of Treatment of Congenital Heart Disease
Section 4: Cardiac Arrhythmias
Chapter 429: Disturbances of Rate and Rhythm of the Heart
Section 5: Acquired Heart Disease
Chapter 431: Infective Endocarditis
Chapter 432: Rheumatic Heart Disease
Section 6: Diseases of the Myocardium and Pericardium
Chapter 433: Diseases of the Myocardium
Chapter 434: Diseases of the Pericardium
Chapter 435: Tumors of the Heart
Section 7: Cardiac Therapeutics
Chapter 437: Pediatric Heart and Heart-Lung Transplantation
Section 8: Diseases of the Peripheral Vascular System
Chapter 438: Diseases of the Blood Vessels (Aneurysms and Fistulas)
Chapter 439: Systemic Hypertension
Part XXI: Diseases of the Blood
Section 1: The Hematopoietic System
Chapter 440: Development of the Hematopoietic System
Section 2: Anemias of Inadequate Production
Chapter 442: Congenital Hypoplastic Anemia (Diamond-Blackfan Anemia)
Chapter 443: Pearson’s Syndrome
Chapter 444: Acquired Pure Red Blood Cell Anemia
Chapter 445: Anemia of Chronic Disease and Renal Disease
Chapter 446: Congenital Dyserythropoietic Anemias
Chapter 447: Physiologic Anemia of Infancy
Chapter 448: Megaloblastic Anemias
Chapter 449: Iron-Deficiency Anemia
Chapter 450: Other Microcytic Anemias
Chapter 451: Definitions and Classification of Hemolytic Anemias
Chapter 452: Hereditary Spherocytosis
Chapter 453: Hereditary Elliptocytosis
Chapter 454: Hereditary Stomatocytosis
Chapter 455: Other Membrane Defects
Chapter 456: Hemoglobinopathies
Chapter 457: Enzymatic Defects
Chapter 458: Hemolytic Anemias Resulting from Extracellular Factors—Immune Hemolytic Anemias
Chapter 459: Hemolytic Anemias Secondary to Other Extracellular Factors
Section 4: Polycythemia (Erythrocytosis)
Chapter 461: Secondary Polycythemia
Chapter 462: The Inherited Pancytopenias
Chapter 463: The Acquired Pancytopenias
Section 6: Blood Component Transfusions
Chapter 464: Red Blood Cell Transfusions and Erythropoietin Therapy
Chapter 465: Platelet Transfusions
Chapter 466: Neutrophil (Granulocyte) Transfusions
Chapter 467: Plasma Transfusions
Chapter 468: Risks of Blood Transfusions
Section 7: Hemorrhagic and Thrombotic Diseases
Chapter 470: Hereditary Clotting Factor Deficiencies (Bleeding Disorders)
Chapter 471: von Willebrand Disease
Chapter 472: Hereditary Predisposition to Thrombosis
Chapter 473: Thrombotic Disorders in Children
Chapter 474: Postneonatal Vitamin K Deficiency
Chapter 476: Acquired Inhibitors of Coagulation
Chapter 477: Disseminated Intravascular Coagulation
Chapter 478: Platelet and Blood Vessel Disorders
Chapter 479: Anatomy and Function of the Spleen
Chapter 481: Hyposplenism, Splenic Trauma, and Splenectomy
Section 9: The Lymphatic System
Chapter 482: Anatomy and Function of the Lymphatic System
Chapter 483: Abnormalities of Lymphatic Vessels
Part XXII: Cancer and Benign Tumors
Chapter 485: Epidemiology of Childhood and Adolescent Cancer
Chapter 486: Molecular and Cellular Biology of Cancer
Chapter 487: Principles of Diagnosis
Chapter 488: Principles of Treatment
Chapter 491: Brain Tumors in Childhood
Chapter 493: Neoplasms of the Kidney
Chapter 494: Soft Tissue Sarcomas
Chapter 495: Neoplasms of Bone
Chapter 497: Gonadal and Germ Cell Neoplasms
Chapter 498: Neoplasms of the Liver
Chapter 499: Benign Vascular Tumors
Chapter 501: Histiocytosis Syndromes of Childhood
Chapter 502: Introduction to Glomerular Diseases
Section 2: Conditions Particularly Associated with Hematuria
Chapter 503: Clinical Evaluation of the Child with Hematuria
Chapter 504: Isolated Glomerular Diseases with Recurrent Gross Hematuria
Chapter 505: Glomerulonephritis Associated with Infections
Chapter 506: Membranous Glomerulopathy
Chapter 507: Membranoproliferative Glomerulonephritis
Chapter 508: Glomerulonephritis Associated with Systemic Lupus Erythematosus
Chapter 509: Henoch-Schönlein Purpura Nephritis
Chapter 510: Rapidly Progressive (Crescentic) Glomerulonephritis
Chapter 511: Goodpasture Disease
Chapter 512: Hemolytic-Uremic Syndrome
Chapter 513: Upper Urinary Tract Causes of Hematuria
Chapter 514: Hematologic Diseases Causing Hematuria
Chapter 515: Anatomic Abnormalities Associated with Hematuria
Chapter 516: Lower Urinary Tract Causes of Hematuria
Section 3: Conditions Particularly Associated with Proteinuria
Chapter 517: Introduction to the Child with Proteinuria
Chapter 518: Transient Proteinuria
Chapter 519: Orthostatic (Postural) Proteinuria
Chapter 520: Fixed Proteinuria
Chapter 521: Nephrotic Syndrome
Chapter 523: Renal Tubular Acidosis
Chapter 524: Nephrogenic Diabetes Insipidus
Chapter 525: Bartter and Gitelman Syndromes and Other Inherited Tubular Transport Abnormalities
Chapter 526: Tubulointerstitial Nephritis
Section 5: Toxic Nephropathies—Renal Failure
Chapter 527: Toxic Nephropathy
Chapter 528: Cortical Necrosis
Chapter 530: Renal Transplantation
Part XXIV: Urologic Disorders in Infants and Children
Chapter 531: Congenital Anomalies and Dysgenesis of the Kidneys
Chapter 532: Urinary Tract Infections
Chapter 533: Vesicoureteral Reflux
Chapter 534: Obstruction of the Urinary Tract
Chapter 535: Anomalies of the Bladder
Chapter 536: Neuropathic Bladder
Chapter 537: Voiding Dysfunction
Chapter 538: Anomalies of the Penis and Urethra
Chapter 539: Disorders and Anomalies of the Scrotal Contents
Chapter 540: Trauma to the Genitourinary Tract
Chapter 541: Urinary Lithiasis
Part XXV: Gynecologic Problems of Childhood
Chapter 542: History and Physical Examination
Chapter 546: Polycystic Ovary Syndrome and Hirsutism
Chapter 547: Neoplasms and Adolescent Screening for Human Papilloma Virus
Chapter 548: Vulvovaginal and Müllerian Anomalies
Chapter 549: Gynecologic Care for Girls with Special Needs
Part XXVI: The Endocrine System
Section 1: Disorders of the Hypothalamus and Pituitary Gland
Chapter 550: Hormones of the Hypothalamus and Pituitary
Chapter 552: Diabetes Insipidus
Chapter 553: Other Abnormalities of Arginine Vasopressin Metabolism and Action
Chapter 554: Hyperpituitarism, Tall Stature, and Overgrowth Syndromes
Chapter 555: Physiology of Puberty
Chapter 556: Disorders of Pubertal Development
Section 2: Disorders of the Thyroid Gland
Chapter 557: Thyroid Development and Physiology
Chapter 558: Defects of Thyroxine-Binding Globulin
Chapter 563: Carcinoma of the Thyroid
Section 3: Disorders of the Parathyroid Gland
Chapter 564: Hormones and Peptides of Calcium Homeostasis and Bone Metabolism
Chapter 565: Hypoparathyroidism
Chapter 566: Pseudohypoparathyroidism (Albright Hereditary Osteodystrophy)
Chapter 567: Hyperparathyroidism
Section 4: Disorders of the Adrenal Gland
Chapter 568: Physiology of the Adrenal Gland
Chapter 569: Adrenocortical Insufficiency
Chapter 570: Congenital Adrenal Hyperplasia and Related Disorders
Chapter 572: Primary Aldosteronism
Chapter 573: Adrenocortical Tumors
Section 5: Disorders of the Gonads
Chapter 576: Development and Function of the Gonads
Chapter 577: Hypofunction of the Testes
Chapter 578: Pseudoprecocity Resulting from Tumors of the Testes
Chapter 580: Hypofunction of the Ovaries
Chapter 581: Pseudoprecocity Due to Lesions of the Ovary
Chapter 582: Disorders of Sex Development
Section 6: Diabetes Mellitus in Children
Chapter 583: Diabetes Mellitus
Part XXVII: The Nervous System
Chapter 584: Neurologic Evaluation
Chapter 585: Congenital Anomalies of the Central Nervous System
Chapter 586: Seizures in Childhood
Chapter 587: Conditions That Mimic Seizures
Chapter 589: Neurocutaneous Syndromes
Chapter 590: Movement Disorders
Chapter 592: Neurodegenerative Disorders of Childhood
Chapter 593: Demyelinating Disorders of the CNS
Chapter 594: Pediatric Stroke Syndromes
Chapter 595: Central Nervous System Infections
Chapter 597: Pseudotumor Cerebri
Chapter 598: Spinal Cord Disorders
Part XXVIII: Neuromuscular Disorders
Chapter 599: Evaluation and Investigation
Chapter 600: Developmental Disorders of Muscle
Chapter 601: Muscular Dystrophies
Chapter 602: Endocrine and Toxic Myopathies
Chapter 603: Metabolic Myopathies
Chapter 604: Disorders of Neuromuscular Transmission and of Motor Neurons
Chapter 605: Hereditary Motor-Sensory Neuropathies
Chapter 606: Toxic Neuropathies
Chapter 607: Autonomic Neuropathies
Chapter 608: Guillain-Barré Syndrome
Part XXIX: Disorders of the Eye
Chapter 610: Growth and Development
Chapter 611: Examination of the Eye
Chapter 612: Abnormalities of Refraction and Accommodation
Chapter 613: Disorders of Vision
Chapter 614: Abnormalities of Pupil and Iris
Chapter 615: Disorders of Eye Movement and Alignment
Chapter 616: Abnormalities of the Lids
Chapter 617: Disorders of the Lacrimal System
Chapter 618: Disorders of the Conjunctiva
Chapter 619: Abnormalities of the Cornea
Chapter 620: Abnormalities of the Lens
Chapter 621: Disorders of the Uveal Tract
Chapter 622: Disorders of the Retina and Vitreous
Chapter 623: Abnormalities of the Optic Nerve
Chapter 624: Childhood Glaucoma
Chapter 625: Orbital Abnormalities
Chapter 626: Orbital Infections
Chapter 627: Injuries to the Eye
Chapter 628: General Considerations and Evaluation
Chapter 630: Congenital Malformations
Chapter 631: External Otitis (Otitis Externa)
Chapter 633: The Inner Ear and Diseases of the Bony Labyrinth
Chapter 634: Traumatic Injuries of the Ear and Temporal Bone
Chapter 635: Tumors of the Ear and Temporal Bone
Chapter 636: Morphology of the Skin
Chapter 637: Evaluation of the Patient
Chapter 638: Principles of Therapy
Chapter 639: Diseases of the Neonate
Chapter 640: Cutaneous Defects
Chapter 641: Ectodermal Dysplasias
Chapter 642: Vascular Disorders
Chapter 644: Hyperpigmented Lesions
Chapter 645: Hypopigmented Lesions
Chapter 646: Vesiculobullous Disorders
Chapter 647: Eczematous Disorders
Chapter 649: Diseases of the Epidermis
Chapter 650: Disorders of Keratinization
Chapter 651: Diseases of the Dermis
Chapter 652: Diseases of Subcutaneous Tissue
Chapter 653: Disorders of the Sweat Glands
Chapter 654: Disorders of Hair
Chapter 655: Disorders of the Nails
Chapter 656: Disorders of the Mucous Membranes
Chapter 657: Cutaneous Bacterial Infections
Chapter 658: Cutaneous Fungal Infections
Chapter 659: Cutaneous Viral Infections
Chapter 660: Arthropod Bites and Infestations
Chapter 662: Tumors of the Skin
Chapter 663: Nutritional Dermatoses
Part XXXII: Bone and Joint Disorders
Section 1: Orthopedic Problems
Chapter 664: Growth and Development
Chapter 665: Evaluation of the Child
Chapter 666: The Foot and Toes
Chapter 667: Torsional and Angular Deformities
Chapter 668: Leg-Length Discrepancy
Chapter 678: Epidemiology and Prevention of Injuries
Chapter 679: Management of Musculoskeletal Injury
Chapter 680: Head and Neck Injuries
Chapter 683: Performance-Enhancing Aids
Chapter 684: Specific Sports and Associated Injuries
Section 3: The Skeletal Dysplasias
Chapter 685: General Considerations
Chapter 686: Disorders Involving Cartilage Matrix Proteins
Chapter 687: Disorders Involving Transmembrane Receptors
Chapter 688: Disorders Involving Ion Transporters
Chapter 689: Disorders Involving Transcription Factors
Chapter 690: Disorders Involving Defective Bone Resorption
Chapter 691: Disorders for Which Defects Are Poorly Understood or Unknown
Chapter 692: Osteogenesis Imperfecta
Section 4: Metabolic Bone Disease
Chapter 694: Bone Structure, Growth, and Hormonal Regulation
Chapter 695: Primary Chondrodystrophy (Metaphyseal Dysplasia)
Chapter 697: Hyperphosphatasia
Part XXXIII: Environmental Health Hazards
Chapter 699: Biologic Effects of Radiation on Children
Chapter 700: Chemical Pollutants
Chapter 701: Heavy Metal Intoxication
Chapter 703: Nonbacterial Food Poisoning
Chapter 704: Biologic and Chemical Terrorism
Chapter 705: Animal and Human Bites
Part XXXIV: Laboratory Medicine
Chapter 707: Laboratory Testing in Infants and Children
Chapter 708: Reference Intervals for Laboratory Tests and Procedures